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Biomedical subjects

Francesco Mancini

Publications and source records attributed to Francesco Mancini.

9 recordsLinked to original sources
PubMed2006

The role of responsibility and fear of guilt in hypothesis-testing.

Recent theories argue that both perceived responsibility and fear of guilt increase obsessive-like behaviours. We propose that hypothesis-testing might account for this effect. Both perceived responsibility and fear of guilt would influence subjects' hypothesis-testing, by inducing a prudential style. This style implies focusing on and confirming the worst hypothesis, and reiterating the testing process. In our experiment, we manipulated the responsibility and fear of guilt of 236 normal volunteers who executed a deductive task. The results show that perceived responsibility is the main factor that influenced individuals' hypothesis-testing. Fear of guilt has however a significant additive effect. Guilt-fearing participants preferred to carry on with the diagnostic process, even when faced with initial favourable evidence, whereas participants in the responsibility condition only did so when confronted with an unfavourable evidence. Implications for the understanding of obsessive-compulsive disorder (OCD) are discussed.

Adult↗
PubMed2006

A hyper-emotion theory of psychological illnesses.

A hyper-emotion theory of psychological illnesses is presented. It postulates that these illnesses have an onset in which a cognitive evaluation initiates a sequence of unconscious transitions yielding a basic emotion. This emotion is appropriate for the situation but inappropriate in its intensity. Whenever it recurs, it leads individuals to a focus on the precipitating situation and to characteristic patterns of inference that can bolster the illness. Individuals with a propensity to psychological illness accordingly reason better than more robust individuals, but only on topics relevant to their illness. The theory is assessed in the light of previous research, a small epidemiological study of patients, and 3 empirical studies.

Affect↗
PubMed2004

Fear of guilt from behaving irresponsibly in obsessive-compulsive disorder.

Previous cognitive models of obsessive-compulsive disorder (OCD) propose that inflated responsibility plays a key role in the maintenance of symptoms (Behav.Res.Ther. 28 (1985) 571). In this manuscript, we propose that this thesis may be improved by emphasizing that instead, OCD may be characterized by a fear of guilt that would result from behaving irresponsibly and/or from not behaving responsibly. We believe that this concept provides a better explanation for the anxious and fearful nature of OCD than do more traditional conceptualizations of inflated responsibility. We support this idea with empirical evidence and propose that OCD symptoms are consistent with patients acting in a prudential mode because of their fears of guilt.

Fear↗
PubMed2004

Manipulation of responsibility in non-clinical subjects: does expectation of failure exacerbate obsessive-compulsive behaviors?

An exaggerated sense of responsibility is currently considered as the ground for the obsessive-compulsive disorder. Obsessive-like behaviors, such as hesitations and checks, may be induced in non-clinical subjects by increasing perceived responsibility (i.e., perceived personal influence on negative outcomes). In line with Salkovskis' proposal [The cognitive approach to anxiety: threat beliefs, safety-seeking behavior, and the special case of health anxiety and obsessions, in: P.M. Salkovskis (Ed.), Frontiers of Cognitive Therapy, Guilford, New York], we tested the hypothesis that reduced coping abilities (i.e., an exaggerated expectation of failure) are another effectual factor contributing to obsessive-like behaviors. We examined 47 normal volunteers in a visuo-spatial memory task, and manipulated their perceived personal influence and expectation of failure by giving differential instructions and feedback about their performance. Increase of perceived personal influence induced slowness, hesitations and checks without enhancing performance. Expectation of failure exacerbated obsessive-like behaviors, again without affecting performance. These results confirm the role of responsibility in obsessive-like behavior and indicate that reduced coping abilities may contribute to worsen dysfunctional strategies.

Achievement↗
PubMed2003

A solid-phase approach towards the development of 3-aza-6,8-dioxabicyclo[3.2.1]octane scaffolds.

The development of new strategies for solid-phase synthesis of 3-aza-6,8-dioxabicyclo[3.2.1]octane scaffolds, named BTKa, is described. The preparation was made possible by the combination of three components: amines, alpha-halo-acetophenones, and sugar or tartaric acid derivatives. By anchoring each of the three components it was possible to synthesize BTKa compounds either as amino alcohols or amido esters. The compatibility of the protocols with different classes of amines and substituted alpha-halo-acetophenones was demonstrated.

Acetophenones↗
PubMed2003

Responsibility, guilt, and decision under risk.

We hypothesize that individuals' choices (risk-seeking/risk-aversion) depend on moral values and, in particular, on how subjects evaluate themselves as guilty or as victims of a wrong rather than on the descriptions of the outcomes as given in the options and evaluated accordingly as gains or losses (framing effect). People who evaluate themselves as victims are expected to show a risk-seeking preference (context of innocence). People who evaluate themselves as guilty are expected to show a risk-averse preference (context of guilt). Responses of 232 participants to a decision problem were compared in four different conditions involving two-story formats (innocence/guilt) and two-question-options formats (gain/loss). Regardless of the format of the question options, the story format appears to be an important determinant of individuals' preferences.

Adult↗
PubMed2002

Obsessions and compulsions and intolerance for uncertainty in a non-clinical sample.

It has been hypothesized that decision-making difficulties in patients with obsessive-compulsive disorder may arise from intolerance for uncertainty. We investigated the relationship between obsessivity and intolerance for uncertainty (defined in terms of need for cognitive closure), controlling for state and trait anxiety and depression. We tested nonclinical subjects through the Need for Closure Scale (NFCS), the Padua Inventory Revised (PI-R), the Beck Depression Inventory (BDI), and the State-Trait Anxiety Inventory (Form-Y; STAI-Y). A principal component analysis showed a lack of correlation between the PI-R and the NFCS subscales. A set of multiple regression analyses performed on PI-R subscales showed that the need for cognitive closure cannot be considered as a strong predictor of obsessions and compulsions. These results speak against the hypothesis that people with high obsessivity have difficulties in taking decisions because of a cognitive need for certainty. We instead argue that difficulties in taking decisions may be related to other specific cognitive beliefs or meta-beliefs.

Adolescent↗
PubMed2002

Role of responsibility in conditional reasoning.

A series of recent studies showed that facilitation on the Wason Selection Task could be produced by perceived utilities. The present work was aimed at testing whether a similar factor could also be involved in human reasoning performance in the context of responsibility. We supposed that the motivation of the subject assuming responsibility is affected by normative goals. These goals prescribe the actions and the results to be achieved, also considering the different social roles. In this experiment the responses of different groups of subjects (N = 270) to a selection task were compared in two different conditions involving different responsibility contexts. The results show that the subjects' strategies in searching for possible violators depended on the condition (responsibility vs no responsibility). In particular, only in the context of responsibility were the performances elicited by conditional rules characterised by a falsification strategy.

Adult↗