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Fraser Hof

Publications and source records attributed to Fraser Hof.

7 recordsLinked to original sources
PubMed2004

Kinetically stable complexes in water: the role of hydration and hydrophobicity.

We describe here the synthesis and characterization of a molecular receptor that forms kinetically and thermodynamically stable host-guest complexes in water. This cavitand-based host is composed of a preorganized aromatic pocket whose rim is decorated with four negatively charged carboxylate groups. (1)H NMR and isothermal titration calorimetry have been used to characterize the behavior of the resulting complexes in response to changes in pH, buffer identity, and salt concentration and in the presence of sodium dodecyl sulfate micelles.

Benzimidazoles↗
PubMed2004

Medicinal chemistry in academia: molecular recognition with biological receptors.

Why carry out medicinal chemistry at a university, when it means competing with the billion-dollar research efforts of the pharmaceutical industry? In academic research, the race to get a drug to market is not the prime motivation. Instead, university-based medicinal chemistry is driven by the search for new knowledge and the opportunity to educate a new generation of chemists. Furthermore, academia can complement commercial efforts by addressing diseases neglected by private industry.

Animals↗
PubMed2002

Molecules within molecules: recognition through self-assembly.

Synthetic molecular receptors that completely surround their target molecules can be created through the use of noncovalent interactions. These molecular capsules selectively sequester guest molecules from the influence of bulk solvent and other molecules on the basis of size, shape, and chemical complementarity. This reversible isolation spawns unique behavior within the confines of the host; the catalysis of chemical reactions and the stabilization of reactive species are possible outcomes that have been recently demonstrated. Compartmentalization of reagents can also have a dramatic effect on reactions that take place outside of the capsule, producing nonlinear kinetics in relatively simple reaction systems.

Catalysis↗