Class 2 integrons in Vibrio cholerae.
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DNA, Bacterial↗
Biomedical subjects
Fumio Kawaguchi
Publications and source records attributed to Fumio Kawaguchi.
Practicality of wavelength selection to improve signal-to-noise ratio in near-infrared spectroscopy.
Near-infrared spectroscopy (NIRS), which can be used to detect changes in the concentration of oxygenated hemoglobin (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb) in tissue by using illumination at two different wavelengths, is often applied to noninvasive measurements of human brain functions. It is common to use two wavelengths that are on opposite sides of the point where the optical absorptions of oxy- and deoxy-Hb are equal (about 800 nm) but an optimal wavelength pair has not yet been determined. In this study, we conducted simultaneous recordings at five wavelengths (678, 692, 750, 782, and 830 nm) to determine the best wavelength for pairing with 830 nm. A theory suggests that pairing a shorter wavelength with 830 nm can provide more sensitivity because of the larger difference in absorption coefficients of hemoglobin between two wavelengths. The changes measured in four cortical areas (frontal, occipital, parietal, and temporal) showed that the noise level when the 678-, 692-, and 750-nm wavelengths were paired with 830 nm was usually lower than when the 782-nm wavelength was paired with 830 nm, which is consistent with theoretical prediction. Moreover, the signal-to-noise ratios (S/Ns) and wavelength dependencies of the power detected in all areas and subjects together suggest that the 692-nm pairing had the highest S/N. This suggests that the optimal wavelengths depend on not only the difference in the absorption coefficients of hemoglobin but also on the optical properties in the measurement area, which affect the strength of the attenuation data. The 692-nm wavelength is thus a more optimal choice than wavelengths around 780 nm for pairing with 830 nm to measure Hb changes induced by cortical activation. The improved S/N enables more sensitive statistical analysis, which is essential to functional mapping with NIRS.
Acoustic Stimulation↗
Successful resection of prostatic rhabdomyosarcoma by the posterior sagittal approach combined with preoperative chemotherapy.
The authors used a posterior sagittal approach to successfully remove a huge prostatic rhabdomyosarcoma from a 3-year-old boy after he had received intensive chemotherapy. This procedure enables safe removal of the prostatic rhabdomyosarcoma under direct vision and with minimal damage to other pelvic organs.
Chemotherapy, Adjuvant↗
A rare case of Salmonella soft-tissue abscess.
A healthy 6-year-old boy had complained of fever and chest pain for 3 days. On admission, he had a mass on the sternum, 3.7 x 2.5 cm in size. Abnormal laboratory findings included a white blood cell count of 12,900/microl, erythrocyte sedimentation rate (ESR), 74 mm/h, and C-reactive protein (CRP), 9.7 mg/dl. Ultrasound examination of the chest revealed a hypoechoic lesion on the sternum that was 30 x 15 mm in size. Chest computed tomography (CT) scan showed no bone fracture or bone erosion. The patient received cefpirome, given intravenously at 60 mg/kg per day for 10 days. Incision and drainage was performed on the seventh day in the hospital, and we collected 0.5 ml of pus. Salmonella enteritidis was detected from the drainage. However, the patient had no gastrointestinal symptoms. He was discharged on the fourteenth hospital day, as he was asymptomatic. Results of all physical and laboratory examinations including blood and stool cultures and ultrasound examinations, were within the normal limits upon discharge.
Abscess↗