[A case of multiple gastric carcinoid tumor with type A gastritis treated by distal gastrectomy].
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Biomedical subjects
Fumio Shimamoto
Publications and source records attributed to Fumio Shimamoto.
Clinical significance of angiogenesis in rectal carcinoid tumors.
This study was designed to examine angiogenesis in rectal carcinoid tumors in relation to the clinicopathologic features. Seventy-seven rectal carcinoid tumors were studied clinicopathologically and experimentally. Cellular proliferation and microvessel density (MVD) were examined immunohistochemically. We used the antibodies MIB-1 for Ki-67, DO7 for p53, and NU-4A1 for CD34 expression in this study. Ki-67 labeling index (LI) of all lesions was below 3%, and the median Ki-67 LI of all lesions was 0.68+/-0.70% (mean +/- SD). A correlation was recognized between tumor size, metastasis and Ki-67 LI (p<0.05). Median MVD of all lesions was 25.9+/-13.1 (mean +/- SD). MVD was correlated with the tumor size (p<0.01), presence of depression (p<0.01), lymphatic (p<0.01) or venous (p<0.05) invasion, and existence of metastasis (p<0.01). But there was no significant relationship between MVD and Ki-67 LI. p53 protein was detected sporadically in only 1 case (1.3%) demonstrating both liver and lymph node metastases. Rectal carcinoid tumors are slow-growing tumors with a lower proliferative activity. Angiogenesis plays an important role in progression of rectal carcinoid tumors independent of the cellular proliferative activity.
Antigens, CD34↗
Frequent loss of heterozygosity on chromosome 10p15, a putative telomerase repressor/senescence gene locus, in gastric cancer.
Previous studies suggest that a telomerase repressor/senescence gene, which acts as a tumor suppressor gene, may be located on chromosome 10p15. However, there are no studies on alterations on chromosome 10p15 in gastric cancers. We, therefore, examined loss of heterozygosity (LOH) on the 10p15 in gastric cancers by microsatellite assay. Two microsatellite loci, D10S501 and D10S602, were used. Fifty-seven gastric cancers, including 36 intestinal type and 21 diffuse type, were selected. LOH at D10S602 and D10S501 was detected in 6 of 18 (33%) and 5 of 27 (19%) gastric cancers, respectively. There was no significant correlation between LOH at these loci and clinicopathologic features, including patient age, sex, tumor location, histologic subtype, depth of invasion, and lymph node metastasis. These data suggest that a putative telomerase repressor/senescence gene may be located on chromosome 10p15, especially at the D10S602, in gastric carcinogenesis, and that the putative gene malfunction may be involved in the early stages of gastric carcinogenesis.
Adult↗
Somatic mutation in mitochondrial DNA and nuclear microsatellite instability in gastric cancer.
It was reported that somatic mutations in the mitochondrial DNA (mtDNA) are associated with high-frequency microsatellite instability (MSI-H) of the nuclear in gastric cancers. However, no correlation between mtDNA mutations and nuclear MSI-H was found in colorectal, breast, and renal cancers. Therefore, the association between mtDNA mutations and nuclear MSI-H in gastric cancers is controversial. We examined mtDNA mutations and nuclear MSI in a large panel of gastric cancers. One-hundred and five gastric cancers were selected. Mutations in the mononucleotide repeat (D310) of mtDNA and nuclear MSI at 5 microsatellite loci were examined by microsatellite assay. Somatic mutations in the mtDNA and nuclear MSI-H were detected in 16 (15%) and 14 (13%) of the gastric cancers, respectively. mtDNA mutations were detected in 2 of the 14 (14%) and 14 of the 91 (15%) tumors with and without nuclear MSI-H, respectively. There was no significant difference between them. These results suggest that somatic mutations in the mtDNA and nuclear MSI-H play important roles in gastric carcinogenesis, and that mtDNA mutations may not be associated with nuclear MSI-H in gastric cancers.
Adult↗
Primary hepatic carcinoid tumor (a case report).
A primary hepatic carcinoid tumor arising in a 77-year-old woman is reported. The patient was admitted with a huge tumor in the right lobe of the liver and treated by an extended right lobectomy of the liver. Light microscopic findings showed that the tumor cells had small oval-shaped nuclei and eosinophilic cytoplasm with small granules forming trabecular, glandular, and rosette patterns. Immunohistochemically, tumor cells were stained positive with neuron-specific enolase and synaptophysin and were stained slightly positive with chromogranin and carcinoembryonic antigen. Careful examination before and after the operation revealed no other origin of the tumor. Based on the findings, the liver tumor was diagnosed as a primary carcinoid. The clinical features and diagnosis of this rare tumor are discussed in this report.
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