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Biomedical subjects

G A Antoine

Publications and source records attributed to G A Antoine.

9 recordsLinked to original sources

Advances in the treatment of lower extremity wounds applied to military casualties.

A review of six patients with severe lower extremity injuries (four of six with grade IIIB tibia fractures), resulting from combat in Somalia, was undertaken to identify patterns of injury, treatment, and problems unique to combat injuries. An AK-47 gunshot was the mechanism of injury in five of six patients. Muscle flaps were required in all patients (four pedicled muscle flaps and three free vascularized flaps), with five of six patients undergoing flap closure during the subacute phase. Ilizarov devices were used in three of four grade IIIB tibia fractures. Five major nerve injuries were identified in three of six patients. The ballistic effect of an AK-47 to the soft tissues of the extremity is not a high-energy wound as seen in civilian blunt trauma. Knowledge of ballistics and the delay in definitive flap coverage secondary to evacuation allowed definition of zones of injury and successful use of local flaps in the majority of our patients. The high number of nerve injuries not commonly described with blunt trauma may prevent full rehabilitation.

Adult↗

Keloid formation on palmar surface of hand.

Keloid formation is never seen on the palms of the hands. The occurrence of a large keloid forming after a surgical procedure performed in the palmar surface of the hand of a black female patient is described. This is the first known case report in English literature.

Adult↗

Dupuytren's contracture and gouty tophi in a black patient.

Dupuytren's disease is a relatively rare occurrence in a patient of the black race. The coexistence of a Dupuytren's contracture in a black patient who also presents with severe gouty tophi is described. This is the first reported case in the English literature.

Dupuytren Contracture↗

Selective non-surgical management of subperiosteal abscess of the orbit: computerized tomography and clinical course as indication for surgical drainage.

Subperiosteal abscess of the orbit (SPA) in childhood is an uncommon but serious sequela of sinusitis, with partial or complete visual loss as the most common complication. Traditional management of SPA has combined systemic antibiotics with immediate surgical drainage. The records of 120 children admitted from 1982-1986 with the diagnosis of periorbital or orbital cellulitis were reviewed. Ten cases of SPA were documented by CT scan (8%). Antecedent ethmoid sinusitis was present in all cases. Five SPA patients were managed with intravenous antibiotics and nasal decongestants alone. All had complete clinical and radiographic resolution without complication. The remaining 5 patients underwent surgical drainage. Two patients required immediate drainage due to total ophthalmoplegia upon presentation. One case of postoperative epidural abscess occurred one week after external fronto-ethmoidectomy among these two patients. The remaining 3 patients did not respond adequately to medical therapy alone and underwent surgical drainage without complication. Length of hospital stay in both medical and surgical groups was similar. We conclude that SPA can be safely managed by medical therapy alone in selected cases. Criteria for surgical intervention of documented SPA while on optimal medical therapy should include: worsening of visual acuity or ocular motility, or failure to improve clinically within 48 h. The presence of SPA alone should no longer be considered an absolute indication for surgery.

Abscess↗

Periorbital cellulitis.

Periorbital cellulitis is a common complication of sinusitis in children. At some hospitals lumbar puncture is routinely done as part of the complete evaluation of children admitted with periorbital cellulitis. Presumably, the lumbar puncture is done to rule out meningitis which could be the result of extension of infection from the orbit to the central nervous system (CNS). However, the degree to which periorbital cellulitis is associated with CNS complication is not known and the necessity for routine lumbar puncture is questioned. Therefore, records of 102 children admitted to the Children's Hospital National Medical Center from 1975 to 1982 with the diagnosis of periorbital cellulitis were reviewed. There were two cases of meningitis and one case of bilateral subdural effusions. Review of the literature and the findings in this study suggests that routine lumbar puncture in seemingly uncomplicated cases of periorbital cellulitis probably is not indicated in children 6 months of age or older.

Adolescent↗

Invasive aspergillosis in a patient with aplastic anemia receiving amphotericin B.

Invasive mycotic infections are becoming more commonplace in immune-compromised hosts. Aspergillus species is the most commonly encountered fungal genus in our environment causing paranasal sinus fungal infection. Aspergillus paranasal sinus infections in the healthy host are readily treated and controlled. In the immune-compromised host this common organism can rapidly become fatal even if recognized and treated appropriately. We present a case history of a patient who died from her disease despite radical surgery and antifungicidal therapy. Recent methods for early diagnosis will be reviewed. Only one other case has been reported in the literature of a patient developing fulminant aspergillosis sinusitis while receiving amphotericin B.

Adult↗