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Biomedical subjects

G A Clarke

Publications and source records attributed to G A Clarke.

26 records · Page 2Linked to original sources
PubMed1988

Spinal anaesthesia for day case surgery.

Postoperative morbidity in fifty day care patients undergoing spinal anaesthesia was evaluated by means of a postoperative questionnaire. Despite the use of a 26G spinal needle in all patients, there was an overall incidence of spinal headache of 18%, which rose to 39% when considering patients under 40 years of age. Several spinal headaches of three to five days' duration were reported. Patients receiving spinal anaesthesia were compared with a smaller group of patients receiving general anaesthesia for similar procedures, and this group showed no evidence of post-operative morbidity after 48 h. In agreement with a previous study, it is concluded that spinal anaesthesia is not a suitable technique for the young day care patient.

Adult↗
PubMed1985

Patient selection for in vitro fertilization: physical and psychological aspects.

The impact of maternal age, previous childbearing, and the type of underlying pathology on the success rate of an IVF program is explored. There is no difference in the pregnancy rate or in the abortion rate with increasing maternal age, and a similar result is seen in relation to previous childbearing. A reduced fertilization rate is seen in couples classified as having unexplained infertility, dyspermia, and male immobilizing sperm antibodies. The pregnancy rates in the first two groups are satisfactory once fertilization has occurred, but there have been no ongoing pregnancies if there are circulating sperm immobilizing antibodies present in either the male or the female. The psychological problems facing the infertile patient are discussed with special reference to in vitro fertilization.

Abortion, Spontaneous↗
PubMed1980

Comparative trial of extra-amniotic and vaginal prostaglandin E2 in tylose gel for induction of labor.

Two hundred and sixty-one patients of varying parity and cervical "ripeness" were given Prostaglandin E2 (PCE2) in tylose gel either vaginally (2.0 mgm) or extraamniotically (0.3 mgm) prior to planned surgical induction. Surgical inductions was avoided in 52 per cent of the vaginal group and 40 per cent of the extra-amniotic group. When subdivided according to parity and cervical ripeness, both groups were comparable except in the multigravid patients with high cervical 'scores', when the vaginal route was significantly more likely to establish labor. Both groups were without significant ill-effects to the mother or fetus.

Amniotic Fluid↗
PubMed1976

Carbon dioxide fixation in Helminthosporium cynodontis.

A mycelial suspension of Helminthosporium cynodontis (ATCC24938), grown on glucose-peptone-yeast extract broth and exposed to NaH14CO3 for 5 h, fixed significant quantities of 14C into the following fractions (%): small molecular weight components, 7-4; lipid and lipoproteins, 3-9; nucleic acids, 59; the residual protein and cell wall fragments, 29-2. The labelled protein components were (%): aspartate, 39; glutamate, 18; cystine, 15; threonine, 9. Radioactive nucleic acid components were (%): adenine, 18; guanine, 18; cytidylate, 34; uridylate, 30. When the mycelium was grown in Czapek-Dox glucose medium and incubated in this medium plus NaH14CO3, the nucleic acid fraction contained 29-9% and the residual protein 49-5% of the cellular radioactivity. The removal of CO2 from the atmosphere did not reduce growth. Pyruvate carboxylase (PC) and phosphoenolypyruvate carboxykinase (PEPCK) activities were demonstrated in extracts of H. cynodontis. Synthesis of PEPCK was stimulated under conditions promoting gluconeogenesis and was reduced under conditions promoting glycolysis, while PC synthesis was similar under both conditions.

Carbon Dioxide↗