Additional benefits of hospice in the nursing home.
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Hospices↗
Biomedical subjects
G A Cooney
Publications and source records attributed to G A Cooney.
Temporal effects of dexamethasone on blood-to-brain and blood-to-tumor transport of 14C-alpha-aminoisobutyric acid in rat C6 glioma.
We used quantitative autoradiography (QAR) to evaluate the effect of systemically administered dexamethasone on capillary permeability in brain tumors and surrounding brain. Rats bearing unilateral right hemispheric C6 gliomas were studied at one and twelve hours after 10 mg/kg of intraperitoneal dexamethasone. Capillary permeability was determined by measuring unidirectional blood-to-brain and blood-to-tumor transport of 14C-alpha aminoisobutyric acid (14C-AIB) over fifteen minutes. 14C-AIB entry into tumor, brain adjacent-to-tumor (BAT), and ipsilateral and contralateral cortices was determined and expressed as a unidirectional transfer constant, K. Nontreated tumor K was more than two-fold greater than K for BAT and ten-fold greater than ipsilateral cortical K, confirming substantial barrier disruption in tumor. In addition, the K for BAT was also significantly greater than K for cortex, indicating that the barrier in the peritumoral region was also disrupted. One hour after dexamethasone treatment, tumor K fell to 63% of its pretreatment value (p less than 0.025). By twelve hours post-treatment, tumor K fell to 25% of the untreated value (p less than 0.001) and to 47% of the one-hour value (p less than 0.005). BAT K fell to 29% of its untreated value (p less than 0.02) and to 46% of its one-hour value (p less than 0.02). By 12 hours, ipsilateral cortical K fell to 67% of the untreated cortical value (p less than 0.05). Compared to untreated values, there was no significant difference between contralateral cortical K at either one or twelve hours.(ABSTRACT TRUNCATED AT 250 WORDS)
Aminoisobutyric Acids↗
EEG frequency analysis in metrizamide radiography.
Computerized frequency analysis was used to quantitate the EEG effects of intrathecal metrizamide in 22 patients undergoing radiographic procedures. In comparison to baseline recordings, no changes were found immediately after the procedure, but a significant (p less than 0.001) shift to lower frequencies was seen at 16 to 26 hours. Individually significant changes were infrequent with lumbar myelograms or low-dose cisternograms and were most prominent in patients who had the combination of high metrizamide dose, cervical level, and a complex procedure with prolonged supine positioning.
Brain Diseases↗