Biomedical subjects
Publications and source records attributed to G A Frassetto.
The effect of clonidine on stress-induced cortisol secretion was studied in 10 patients undergoing general anesthesia for surgery; six other patients served as a control group and none of them was given clonidine. Central and peripheral alpha 2 stimulation by clonidine (average dose:0.45 mg over 60 minutes) was able to completely suppress cortisol release during surgery.
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The Authors present a case report of a spontaneous ruptured aneurysm of the superior pancreaticoduodenal artery (retropancreatic arterial arch), leading to a massive retroperitoneal hemorrhage with very severe hemorrhagic shock. They point out the rarity of such instances and explain some of the etiopathogenic, clinical and therapeutic aspects of this type of hemorrhagic pathology.