PubMed Health⌕ Search

Biomedical subjects

G A Gaĭdina

Publications and source records attributed to G A Gaĭdina.

At least 19 recordsLinked to original sources
PubMed1976

[Effect of thyrotoxicosis on the activity of proprioceptors of the skeletal muscles].

A study was made of the influence of prolonged administration of the thyroid hormones on the pulse activity of the cat soleus muscle spindles. In the animals with thyrotoxicosis the response of the primary endings of the spindles on the continuously acting and sudden rapid extension proved to be considerably enhanced both during the dynamic and the static phase. The frequency of discharges of the secondary endings showed no significant changes. It is supported that the changes in the activity of the primary endings observed were connected with the disturbances in the metabolism of the muscle and also with its atrophy.

Animals↗
PubMed1976

[The effect of thyroid hormones on inhibition of monosynaptic extensor reflexes].

In thyreotoxic cats with intact or transected spinal cord, intensity of direct and presynaptic inhibition induced by a single volley in a flexor nerve afferent fibers was diminished and the delayed postsynaptic (polysynaptic) inhibition from the skin afferent fibers was more intense than in control cats. The mechanisms for the thyroid hormone effect on the cerebrospinal control of the extensor reflex inhibition, are discussed.

Animals↗
PubMed1975

[Analysis of the causes of increased tremor in thyroid hyperfuction].

The authors present the results of examination of tremor (hand and trunk) of the amplitude of H- and T-reflexes and of the H-reflex inhibition during the contraction of antagonistic muscles and of facilitattion of T- and H-reflexes during the Yendrassik maneuvre in 33 children with hyperfunction of the thyroid gland and 20 normal subjects. It was established that the amplitude of tremor was greater and the frequency was less in these patients than in normal subjects; the amplitude of the H- and T-reflexes was enhanced, and the intensity of reciprocal inhibition of the soleus muscle motor neurons was less in the patients. Comparison of the amplitude of the T- and H-reflexes indicated that against the background of the Yendrassik maneuvre facilitation of the T-reflex was less intense and facilitation of the H-reflex was more intense than in normal subjects. The authors supposed that the enhanced tremor in the patients was due to the motor neurons pool depolarization, to decrease the efficacy of reciprocal inhibition and to diminished suprasegmental influences spread to the gamma-motor neurons.

Adolescent↗
PubMedDate not supplied

[Disturbance in the function of the spinal centers in diffuse toxic goiter in children (electromyographic study)].

Peculiarities of the reflex and motor responses of the soleus muscle were studied in stimulation of the tibial nerve by stimuli of gradually increasing intensity, and also in double stimulation and against the background of contraction of the antagonistic muscles in children with diffuse goiter and in healthy individuals. In sick children an increase and a fall in the H-response amplitude with increase of the stimulation intensity occurred more rapidly than in healthy ones. A rapid restoration of the reflex response at the interval of 500 msec and greater was noted in studying the cycle of restoration of excitation of the motor cells of the anterior horn in sick children. Against the background of contraction of the antagonistic muscles the reciprocal inhibition of the reflex response of the muscle was weaker than in the healthy individuals. The data obtained led to a supposition that one of the causes of motor disturbances in case of an excess of the thyroid hormones in the organism could be a disturbance of the processes of the pre- and postsynaptic inhibition at the spinal level.

Adolescent↗
PubMedDate not supplied

[The treatment of diffuse euthyroid goiter with indomethacin].

Clinico-instrumental and hormonal investigation of 31 patients with diffuse euthyroid goiter was conducted. To test the efficacy of indometacin as an antigoitrogenic drug, these patients were given it for 2 mos. Combined examination of the patients showed the absence of thyroid decrease and changes in thyroid function against a background of indometacin monotherapy. The results point out to the fact that the drug should not be used for elimination of thyroid hyperplasia in persons with diffuse euthyroid goiter.

Adolescent↗
PubMedDate not supplied

[Hypothalamo-mesencephalic crises in endocrine diseases].

Altogether 261 patients with different vegetative crises were investigated by clinico-neurologic, electro-, rheo-, echoencephalographic methods. The most frequent causes of crises (in 140 patients) were disorders of the hypothalamic and hypothalamo-mesencephalic sections of the brain. In the rest of the patients crises were caused by neuroses, disorders of the caudal zones of the brain stem and temporal region, pheochromocytoma, insulinoma, primary hyperaldosteronism, hypoparathyroidism and other diseases. Criteria of differential diagnosis of hypothalamic crises and crises in neuroses, disorders of the distal sections of the brain stem and temporal lobe epilepsy were specified. Some new, quite informative clinico-neurological and rheo- and electroencephalographic criteria were proposed for the differentiation of hypothalamic crises and crises in pheochromocytoma, insulinoma and primary hyperaldosteronism.

Acute Disease↗
PubMedDate not supplied

[Changes in the duration of the Achilles reflex in euthyroid goiter in children].

Changes in the duration of the Achilles reflex were studied in subclinical disturbances of thyroid function. For this purpose the duration of the Achilles reflex, the levels of T4, T3, iodine protein bound TSH and cholesterol were investigated in children admitted to hospital with the general diagnosis of the "euthyroid goiter". Clinical and laboratory findings revealed subclinical types of the diffuse toxic goiter, hypothyrosis, chronic thyroiditis, endemic goiter, nodular goiter, pubertal struma and sporadic euthyroid goiter. The aim of the study was to define the diagnostic importance of reflexometry in subclinical disorders of thyroid function and to assess the relationships between metabolic derangements and the duration of the Achilles reflex. Changes in the duration were shown to correspond to disorder of thyroid function. In 76% of the cases reflexometry brought about the correct assessment of the patient's thyroid status. A significant conformity of the levels of TSH, T3, T4 to the duration of the Achilles reflex was shown.

Achilles Tendon↗
PubMedDate not supplied

[Reflex excitability of the spinal centers in patients with diffuse toxic goiter (concerning the pathogenesis of motor disorders)].

Reflex activity of the spinal cord motor centres was studied in patients with diffuse toxic goiter and in healthy persons. Methods of recording N- and M-responses of the soleus muscle were used. It was revealed that the number of motor neurons participating in the reflex reaction was changed; the restoratory cycle of the motor neuron pool was disturbed in double stimulation; inhibition of the H-reflex during the voluntary contraction of the antagonist muscle was diminished. The occuring disturbances were connected with the functional changes both of the segmental spinal cord apparatus and of the supersegmental formations. The extent and the direction of the detected disturbances are determined by the presence or the absence of affection of the mesodiencephalic formations on the patients under study and failed to depend on the severity of the disease.

Action Potentials↗
PubMedDate not supplied

[Function of the neuromotor apparatus in diabetes mellitus].

Peculiarities of the reflex and motor responses (H-and M-responses) of the soleus muscle in stimulation of the tibial nerve were studied in 69 patients with diabetes mellitus and in 44 healthy persons. The ratio of the maximal amplitudes of the H/M potentials studied usually decreased in patients with diabetic polyneuropathy in comparison with analogous indices in healthy persons. However, in the presence of labile or ketoacidotic forms of diabetes H/M increased considerably. Accelerated restoration of the H-reflex amplitude in coupled stimulations of the nerve in such patients indicated intensification of the facilitating cerebrospinal influences. A marked increase of the tendon and H-reflexes amplitude in patients with diabetes against the background of Jendrassik's method pointed to a possible deafferentation of the spinal centres. The results obtained indicated that, irrespective of the manifestations of the neuropathy symptoms, there were functional disturbances of both the segmental and suprasegmental formations controlling the motor function.

Achilles Tendon↗