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Biomedical subjects

G A Gerasimov

Publications and source records attributed to G A Gerasimov.

At least 19 recordsLinked to original sources
PubMed1990

[Pharmacodynamic metoclopramide (cerucal) test in differential diagnosis of hypoprolactinemic hypogonadism syndrome in women].

Roentgenology revealed pituitary macroadenoma in 13 of 67 women with hyperprolactinemia. Craniographic structural abnormalities of the sella turcica suggested pituitary microadenoma in 20 women. Metoclopramide (cerucal) test was performed in the patients and a control group of 9 healthy women. Blood concentrations of prolactin (prolactin, somatotropic thyroid-stimulating hormone) were determined with a radioimmune assay. Significant disorders of the hypothalamo-pituitary control were detected, presenting as depressed and delayed prolactin and TSH response in this assay. The neuroendocrine disorders were most severe in patients with macroprolactinoma who showed a refractory prolactin secretory response to dopaminergic metoclopramide inhibition. The patients with microprolactinomas had a low prolactin response (increments less than 300-400%) and delayed TSH response. The metoclopramide test is recommended for differential diagnosis of hyperprolactinemic syndrome.

Adult↗
PubMed1990

[Hyperprolactinemia syndrome in men].

A total of 122 male subjects suffering from secretory infertility were examined. In 25 of them (20 percent) blood prolactin levels were above the norm. Measurements of basal prolactin levels and of its secretion in metoclopramide test helped distinguish two types of hyperprolactinemia syndrome, differing in the pattern of spermatogenesis disorders. Possible pathogenesis of individual types of hyperprolactinemia in men is discussed. Therapy with dopamine agonists (lisenyl, parlodel) was found most effective in Type I hyperprolactinemia syndrome, associated with essential prolactin hypersecretion and oligospermia.

Adult↗
PubMed1989

[Effectiveness of lysenyl-forte treatment in acromegaly and hyperprolactinemia syndrome].

Lysenyl-forte, a derivative of polysynthetic ergot alkaloids, producing a dopaminergic and antiserotoninergic action was employed to treat acromegaly and prolactin hypersecretion in 11 and 71 patients, respectively. Clinical effect was established basing on a complex of clinical, x-ray, neuro-ophthalmologic and hormonal evidence. Acromegaly treatment proved efficient: 7 patients (63%) showed partial relief of clinical signs, reduced STH blood level. Out of 48 patients with prolactinemia a response was registered in 34 (71%): a more than 50% decrease in prolactin concentration, normal levels of the hormone in 35% of the patients. A menstrual cycle recovered, galactorrhea diminished, 2 women got pregnant. A positive effect was noticed in management of 13 sterile men with prolactin hypersecretion, in 6 patients with idiopathic prolactin hypersecretion, in 4 women with primary hypothyrosis and galactorrhea. Compared to parlodel, lysenyl was not superior in the frequency of side effects, though was inferior in clinical effectiveness. The drug is recommended for wide-scale use.

Acromegaly↗
PubMed1988

[Success of a parlodel test in the differential diagnosis of syndromes of disturbed prolactin secretion].

Altogether 33 women with various forms of the syndrome of hyperprolactinemia (hypophyseal adenoma, idiopathic disorders of prolactin secretion--PL, and normoprolactinemic galactorrhea) and 6 controls were investigated. An acute parlodel test at a dose of 5 mg with subsequent determination of the blood levels of PL and TSH was performed in 2 and 4 h after drug administration. The most noticeable disorders in the dopaminergic regulation of pituitary activity were observed in pituitary adenomas which were characterized by a dramatically disturbed response of PL and TSH to parlodel. In hyperprolactinemia of nontumorous genesis PL and and TSH secretion in tests was also changed. The parlodel test seems to be a valuable method for differential diagnosis of the syndrome of disturbed PL secretion.

Adenoma↗
PubMedDate not supplied

[Comparison of the data of palpation and ultrasonic examination in assessing the dimensions of the thyroid gland].

Comparison of the thyroid-sizes estimated by palpation and ultrasonic scanning in 282 women and 178 men has shown that if the thyroid is small (from 0 to 2nd degree, according to O. V. Nikolayev's classification), its size cannot be estimated by palpation and this method fails to assess the endemic goiter in epidemiologic surveys. Correlation between the thyroid size estimated by palpation and its ultrasonically assessed volume has made up 0.346 (p < 0.001) in women and 0.193 (p < 0.01) in men. Ultrasonic assessment of the thyroid volume appears useful both for clinical and epidemiologic studies.

Female↗