PubMed Health⌕ Search

Biomedical subjects

G A Gilbert

Publications and source records attributed to G A Gilbert.

15 recordsLinked to original sources
PubMed1986

Pharmacokinetics of cefoperazone in the cow by the intramammary route and its effect on mastitis pathogens in vitro.

The pharmacokinetic and microbiological properties of a new third generation cephalosporin, cefoperazone, when given by the intramammary route to the cow are described. Cefoperazone is excreted from the udder over a three- to five-day period following a single infusion of 250 mg in an oil base into each of all four quarters. By the fifth milking after treatment the mean bucket (composite) concentration of cefoperazone was below 0.01 microgram/ml. The minimal inhibitory concentrations for 470 pathogens isolated from cases of mastitis were determined. A few exotic species were resistant but all the usual isolates were sensitive. No signs of transferable drug resistance from known multiple drug-resistant strains were detected.

Animals↗
PubMed1986

Field trials with cefoperazone in the treatment of bovine clinical mastitis.

A single dose of 250 mg cefoperazone in an oil based suspension infused into bovine quarters suffering from clinical mastitis resulted in an overall clinical cure of 82 per cent in 597 cases, as assessed by veterinarians in four countries (Sweden, Denmark, France and the United Kingdom). Of those cases for which adequate bacteriological data were available 69 per cent of 434 cases were cured. There were no reports of adverse reactions following therapy of an affected quarter. The introduction of single dose treatment represents an advance in mastitis therapy as it offers a simpler and shorter treatment than most present day mastitis therapeutics when used according to recommendations.

Animals↗
PubMed1979

Equine parasite control using pyrantel embonate.

Over a period of several years the use of pyrantel embonate in the control of helminth infections on three equine establishments was monitored by the examination of faecal samples collected immediately before each anthelmintic treatment. With a monthly interval between treatments for three years the faecal egg output of the horses remained at a very low level. One one establishment this was maintained when the treatment interval was extended to one-and-a-half months after treating monthly for two years. If a treatment interval of one-and-a-half months was used continuously for a number of years there was a cumulative effect, and the benefits, in terms of reduced faecal egg output of the horses, were more apparent during the second year of the control programme.

Animals↗
PubMed1975

Evaluation of the precision of difference chromatography.

Difference chromatography, a method of chromatography in which elution volumes are compared directly, has been tested for precision under conditions used for estimating the relative dissociation of human oxyhaemoglobin and methaemoglobin and their hybrid. The test was carried out by first establishing a steady flow of haemoglobin through a column of gel particles, and then interrupting the flow temporarily by injecting a known weight of buffer solution, which thus simulated a small difference in elution volume. The dip in absorbance on the elution record was evaluated by digital methods. Statistical analysis of the results showed that the injected weight was estimated from the elution record with a standard error of plus or minus 0.02 g. Since the elution weight was about 50 g, the precision of difference chromatography must approach that of difference ultracentrifugation, and has obvious potential for the accurate comparison of the molecular weights of polypeptides in strongly dispersing media.

Chromatography, Gel↗