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Biomedical subjects

G A Godette

Publications and source records attributed to G A Godette.

8 recordsLinked to original sources
PubMed1996

Biomechanical effects of gamma irradiation on fresh frozen allografts in vivo.

The effect of gamma irradiation on the mechanical properties of allograft in a rabbit model was examined. Tibial allografts were tested in torsion to failure to determine maximum torque and maximum stress. Statistically significant degradation in the torsional strength of irradiated tibias vs controls was demonstrated. Femoral allografts were orthotopically implanted into experimental rabbits and secured with an intramedullary pin. Rates of incorporation and failure patterns were significantly altered by irradiation. These data suggest that sterilization of fresh-frozen allografts with 2.5 Mrad or greater severely degrades the ability of the graft to resist torsion. The rate of incorporation of fresh-frozen allografts also may be dramatically decreased as a result of irradiation.

Animals↗
PubMed1993

Medial triceps flap coverage for an ulnar neuroma.

This paper reports on a technique for coverage of a posttraumatic lateral neuroma at the elbow. A 14-year-old male patient underwent exploration of the ulnar nerve 4 months after a laceration to the elbow. Following neurolysis and anterior submuscular transposition, the exposed neuroma was covered using a flap of medial triceps muscle. The flap required minimal mobilization, incurred little donor morbidity, and provided adequate coverage without the danger of creating a new area of compression.

Adolescent↗
PubMed1993

Is pinning in situ a safe procedure for slipped capital femoral epiphysis?

This report reviews the results of 37 patients with 46 involved hips treated with pinning for slipped capital femoral epiphysis. Particular attention was given to incidence of complications, including avascular necrosis, chondrolysis, and penetration of the joint. Of 46 hips with 1-year follow-up, there were no cases of chondrolysis. Of 23 hips with 2-year follow-up, there was only 1 case of avascular necrosis. Pin penetration, recognized at the time of surgery, produced no significant sequelae. Pinning can produce satisfactory results without a significant incidence of major complication.

Adolescent↗
PubMed1990

Synergistic effects of vinblastine and recombinant interferon-beta on renal tumor cell lines.

Potential synergistic interactions between vinblastine (VBL) and recombinant interferon-beta (rIFN-beta) were assessed using median effect analysis. Calculation of the combination index demonstrated values less than 1 (indicating synergy) over a wide range of drug-induced growth inhibition for each of four different renal carcinoma cell lines (RCC). The degree of synergy observed could not be predicted from the morphology, doubling time, or relative sensitivity of the RCC lines to VBL and rIFN-beta. The optimal ratio of VBL to rIFN-beta in the combination appeared to be close to the ratio of the concentrations of each agent which yielded a 50% inhibition of growth. Although simultaneous presence of VBL and rIFN-beta in the culture medium was not required to demonstrate a synergistic effect, the minimum exposure time for rIFN-beta was determined to be 7 days. The uptake but not the egress of tritiated VBL into RCC cells was enhanced after growth for 4 days in 2.25 ng/ml of rIFN-beta. Median effect analysis can be shown to be independent of the mechanism of action of VBL and rIFN-beta and gives an indication of potential synergistic interactions over a wide range of drug effects. This method may prove useful in the selection of combinations of IFNs and antitumor drugs for clinical study.

Cell Division↗
PubMedDate not supplied

Plantar fibromatosis of the heel in children: a report of 14 cases.

Based on a study of 14 patients younger than 16 years, we found that lumps on the plantar aspect of the anteromedial portion of the heel pad can safely be observed. Many remained small and asymptomatic, some disappeared, and two that required repeated excision biopsy did not subsequently recur. The six patients who were subjected to excision biopsy were found to have plantar fibromatosis. This very precise heel site is a characteristic situation for plantar fibromatosis in childhood.

Adolescent↗