PubMed Health⌕ Search

Biomedical subjects

G A Mayer

Publications and source records attributed to G A Mayer.

9 recordsLinked to original sources
PubMed1976

Blood viscosity and oral anticoagulant therapy.

During administration of bishydroxycoumarin, hematocrit, viscosity of whole blood, and viscosity of plasma decreased in samples from nine healthy volunteers and 31 patients who had coronary heart disease. The relationships between viscosity of blood and intensity of anticoagulant therapy varied from patient to patient. Discontinuation of the drug was followed by return of viscosities to pretreatment levels in two to four days. The decrease of viscosity of blood by anticoagulant therapy may explain the relief of anginal pain in patients who have coronary heart disease.

Administration, Oral↗
PubMed1974

Instability of nitroglycerin tablets.

Nitroglycerin is a volatile substance which evaporates from tablets if strict precautions are not taken. The tablets kept in small, amber, tightly capped glass bottles in a refrigerator maintain their potency for three to five months if bottles are opened once a week. After five months the unused tablets should be discarded. Tablets kept in a pill box and carried with the patient will deteriorate in a week and should be discarded thereafter. Cotton, plastic or paper stuffed in the bottle and frequent opening will reduce the potency of NG tablets considerably. Physicians, pharmacists and drug manufacturers should supply full instructions to patients on how to prevent rapid deterioration of their supply.

Angina Pectoris↗
PubMed1965

Hematocrit and coronary heart disease.

Hematocrit values of patients with acute myocardial infarction have been reported by some workers to be higher than those found in controls; this has been denied by others. In these reported studies important postural, postprandial, age and stress effects have not been considered. In the present investigation hematocrits of healthy and coronary subjects were determined under the same "standard basal" conditions, in the morning hours, fasting or after a light breakfast, and in sitting position; patients studied had no acute illness or distress. A mean hematocrit of 49.1 +/- 2.4% was observed in 66 men with chronic coronary disease and of 46.8 +/- 3.2% in 68 healthy controls of the same age and sex, the difference being highly significant. The increased hematocrit and plasma viscosity in coronary patients creates significantly higher whole blood viscosity than that observed in healthy controls. This hemodynamic factor may be responsible for the development of clinical symptoms of coronary heart disease and possibly of the basic vascular disease itself.

Adult↗
PubMed1965

Diurnal, postural and postprandial variations of hematocrit.

The microhematocrit (HCT) values of 59 subjects increased significantly in the sitting position and after moderate exercise, in comparison with the values obtained during recumbency. The consumption of an 800-calorie meal decreased the HCT and this effect lasted for six hours. In order to obtain comparable results blood for HCT should be taken in a "standard basal condition" in the morning hours, in the fasting state or after a light breakfast, and the patient should sit for at least 30 minutes before the blood specimen is taken.

Blood↗