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Biomedical subjects

G A Pan'shin

Publications and source records attributed to G A Pan'shin.

At least 19 recordsLinked to original sources
PubMed2006

[Ten-year outcomes of lymphogranulomatosis treatment according to the protocol MOPP-ABVD+radiotherapy].

AIM: To analyse overall recurrence-free survival of lymphogranulomatosis (LGM) patients given polychemotherapy (PCT) MOPP (mustargen-caryolisin, vincristine, natulan, prednisolone) - ABVD (adriamycin, bleomycin, vinblastin, dacarbasin) in combination with radiotherapy (RT) for 10 years. MATERIAL AND METHODS: The trial included 211 LGM patients admitted to Hematological Research Center in 1990-1996 from other hospitals without random selection. The patients were examined by the standard program including biopsy of the affected organ or lymph node, bilateral trephine biopsy. Splenectomy was performed in 17 patients, 83 patients received PCT in other hospitals, 128 untreated patients received MOPP-ABVD therapy (3 courses of MOPP and 3 courses of ABVD). Forty one patients had defects in PCT, 16 of them rejected PCT and RT. The latter was performed 4 weeks after the 6th course, contraceptives were not prescribed to women. At LGM stage II-III RT was performed by the subradical program (no radiation to ilioinguinal lymph nodes) in doses 40-44 Gy on the foci and 32-36 Gy preventively, on massive and residual foci after PCT - 5-10 Gy additionally. RESULTS: Ten-year overall and recurrence-free survival in the untreated group reached 83 and 80%, respectively, for pretreated patients - 46 and 36%, respectively. Causes of death of 26 patients were LGM progression, infection (tuberculosis, as a rule), secondary tumors and acute myeloblastic leukemia (AML). After remission 25 women gave birth to a healthy child and 12 healthy children were born to 9 males. CONCLUSION: MOPP-ABVD plus radiotherapy program according to subradical and radical variants was in the past effective but invalidating rescue therapy. Present-day programs consider the histological variant, stage and prognostic factors allowing an individual therapeutic approach with step-by-step reduction of RT in the treatment of LGM patients. Involvement of the bone marrow in primary patients had no influence on the treatment results. This refers this affection not to a generalized stage IV, but to stage III along with involvement of the lymph nodes and the spleen.

Adolescent↗
PubMed2006

[Radiation assisted diagnosis and complex treatment of penile carcinoma].

Recurrence-free survival rate after conservative treatment of penile carcinoma was as high as 81%. The best results were obtained with use of combined radiotherapy (monotherapy and telegamma therapy concurrent with penile resection or circumcision) (91.6 and 75%, respectively). Organ-saving treatment was most effective in T1-T2 penile carcinoma while MRI yielded the most reliable diagnostic evidence on depth of primary tumor invasion and regional lymph node involvement.

Adult↗
PubMed2005

[Novel approaches to combination therapy of Hodgkin's disease].

Data on 668 patients receiving 4-8 cycles of chemotherapy were used to suggest the following approach to complex therapy of Hodgkin's disease: devise a simplified model for Hodgkin's disease, develop a new modality of chemotherapy, demonstrate feasibility of only four chemotherapy cycles in the poor prognosis group, partial response as the ultimate goal of chemotherapy as well as the importance of subtotal dosage under 26-36 Gy sufficient for irradiation of the entire lymphatic collector. Said measures will, in their totality, offer fresh opportunities in treatment of Hodgkin's disease.

Adult↗
PubMed2000

[Experience with and perspectives of an extended radical regimen of radiotherapy for Hodgkin's disease with prophylactic irradiation of the liver and the lungs].

The end-results of extended radical radiotherapy for stage II-III Hodgkin's disease with apparent factors of risk of relapse in the lung and/or liver are presented. The procedure included prophylactic irradiation of both organs. Ten-year relapse-free survival in the lung-irradiation group was 85.9%, overall 10-year survival--94.0%; the liver-irradiation group--90.0 and 94.7%, respectively. Preventive irradiation was shown to significantly decrease the influence of such risks as extended lesions of the mediastinum and spleen. Relapse in the lung was recorded in one case (1.6%) only, with no tumor progression defected in the liver. Significant increase in 5- and 10-year relapse-free survival was established in the lung-irradiation group, as a result of a comparison of the study group and that of controls who showed characteristic signs of intrathoracic risk. Significant difference in overall survival was recorded for the first three years only. As far as the liver-irradiation factor is concerned, the rise in both categories of survival was significant for the 10 years. It is suggested that patients with stage II-III Hodgkin's disease receive prophylactic irradiation whenever they reveal significant signs of risk of relapse in the lung and/or liver.

Adult↗
PubMed2000

[Role of induction chemo- and radiotherapy in the treatment of locally advance breast cancer].

336 patients with locally-advanced breast cancer underwent neoadjuvant chemotherapy or chemoradiotherapy. Increase in T- and N-indices (change of stage after neoadjuvant chemotherapy) proved an important prognostic factor. Survival rates correlated with clinical effect and dropped as it diminished. This tendency was clear in both groups. There was no relationship between stage and overall and disease-free survival rates at early stages but later they declined as T- and N-indices decreased.

Adult↗
PubMed1999

[Results of combined treatment of patients with rectal cancer using a single preoperative radiotherapy dose of 7.5 Gy].

The results of 3-year combined and surgical treatment of 173 patients with rectal tumors are discussed. Single dose of 7.5 Gy was administered to 83 patients on the eve of radical surgery. Ninety patients in control received radical surgery alone. One-, two- and three-year radical cure rates in the study group were higher by 22.9, 21.2 and 29.3%, respectively, while 3-year recurrence-free survival in the same group was 2.7 times that in the surgical patients.

Adult↗
PubMed1999

[Single preoperative radiation exposure for stage II breast cancer].

The efficacy of different combinations of radiotherapy and mastectomy after Madden was compared in 411 patients with stage II breast tumors. The least likelihood of local reccurence (4.5 +/- 1.3%) was recorded after single exposure before mastectomy and with/without adjuvant irradiation of the regional lymphatics (group I); it appeared 1.5 times as high (7.0 +/- 2.1%) after mastectomy + postoperative irradiation (group II) while the highest frequency (14.8 +/- 5.4%) was registered after surgery alone (group III). Relapse-free 10-year survival was observed in 63.5 +/- 4.7 (group I), 77.4 +/- 4.6 (group II) and 46.2 +/- % (group III), respectively, the difference between group I and II being significant. Therefore, postoperative radiotherapy in conjunction with mastectomy (Madden) should be recommended for stage II breast carcinoma when the breast cannot be salvaged.

Breast Neoplasms↗
PubMed1999

[Monitoring the changes of the lesion and of the patient's health condition in the course of radiotherapy].

The effect of therapy of malignancies is at present monitored by X-ray procedures on the basis of the dynamics of the size of lesion. Since such approach fails to provide data on the structure of lesion changes and response to treatment, it is suggested that structural changes in cells of exposed tissues can by monitored by using densitometric data obtained from mammograms and (computed) tomograms, to assess density changes in tumor and adjacent normal tissues. Recovery involves certain systemic changes which can be identified using certain peripheral blood indices; the latter are evaluated using non-statistical applications of the theory of pattern recognition and cluster analysis.

Aged↗
PubMed1999

[Lung cancer: 30-year experience of surgical and combined treatment].

6,212 lung cancer patients have been examined and treated. The data on surgical and combined treatment of 2,702 patients have been analyzed. Postoperative complication incidence has dropped to 5.4% in recent years. End results have improved due to use of organ-saving, reconstructive and plastic procedures for the bronchi and trachea in conjunction with radiotherapy.

Adult↗
PubMed1997

[Current technology of radiotherapy in the conservative treatment of localized breast cancer].

New procedures of radical radiotherapy for localized breast tumors have been developed. They offer high precision and a close fit of irradiation fields. Conservative treatment was given to 108 patients. Five- and ten year-survival, recurrence-free, following radical chemoradiation therapy was 30.2 and 14.1%, respectively: overall survival--33.6 and 15.5%, respectively. No signs of locoregional progression of tumor was observed in 77.5%. An evaluation of the results of complex treatment including obligatory mastectomy and those of conservative therapy revealed obvious advantages of the former in dealing with T3N1-2M0 tumors. However, no advantage was recorded in the treatment of T4N1-2M0 tumors. Radical chemo-radiotherapy of localized T4N1-2 tumors or respective single supraclavicular lymph nodes may be considered an alternative to modalities including mastectomy, provided all procedural and technological requirements are met.

Breast Neoplasms↗
PubMed1997

[Expert system for establishing indications for radiation and combined therapy of patients with non-hodgkin's lymphoma].

Mathematical procedures have been employed which enable to carry out automatic selection within small groups of patients with primary non-Hodgkin's disease, with a view to choose between chemoradiation, radiation or drug therapy. The study included 670 patients, aged 15-79, who were followed up for 1-10 years. Groups were formed on the basis of the following prognostically-significant parameters: sex and age, histological pattern and stage, primary localization and maximal size of tumor (involvement of the mediastinum, bone marrow and peripheral blood). Each group was conceived on the basis of two or three parameters. The efficacy of each therapeutical modality was assessed using the data on overall and recurrence-free survival. A computerized program was used for making prognosis for each patient which, in turn, determined the choice of the most effective type of treatment.

Adolescent↗
PubMed1996

[The grouping of morphological variants of non-Hodgkin's lymphomas (lymphosarcomas) by the degree of malignancy].

The authors stated that WHO classification allows identification of two groups of morphological variants of non-Hodgkin's lymphomas: low- and high-grade malignancy. These differ by principal clinical characteristics, incidence of complete and partial remissions, survival duration. The analysis of clinical course, long-term and short-term treatment outcomes is provided for 674 patients with the above lymphomas.

Adolescent↗
PubMed1991

[Risk factors and survival prognosis in lymphogranulomatosis: a statistical analysis].

To examine risk factors and to design prognostic models for the total, relapse-free and after-relapse survival, use was made of the Cox model for unifactorial and multidimensional analysis based on the retrospective estimation of the results of the treatment of 235 patients with lymphogranulomatosis, stages II-III. Radiotherapy according to the radical program was carried out in conjunction with polychemotherapy according to the COPP scheme. The number of areas of damage, massiveness of injury to the mediastinum, involvement of the spleen into the process appeared the most informative risk factors for predicting both total and relapse-free survival. The prediction of the after-relapse survival was considerably influenced by the age combined with carrying out of not less than 3 cycles of polychemotherapy given to the patients during initial treatment or with the presence of intoxication symptoms and increased ESR. The tables of the survival probability were calculated.

Antineoplastic Combined Chemotherapy Protocols↗