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Biomedical subjects

G A Romanov

Publications and source records attributed to G A Romanov.

At least 19 recordsLinked to original sources
PubMed2004

[Endoscopic assay and surgery at chronic pancreatitis].

OBJECTIVE: To assess the possibilities of endoscopic surgeries at the pathology of major duodenal papilla in patients with the painful form of chronic pancreatitis. The study involved 35 patients with the painful form of chronic pancreatitis including 19 subjects with cholecystectomy as a result of cholelithiasis, 8 subjects with alcohol-induced pancreatitis (4 of them had external pancreatic fistulas) and 8 patients with idiopathic pancreatitis. As many as 60 different X-ray and endoscopic procedures were carried out altogether: ERCPG, EPST and dissection of pancreatitis duct entrances as well as nasopancreatic drainage and stenting. ERCPG discovered the pathology of major duodenal papilla in the form of stenosis of the common bile duct entrance and/or main pancreatic duct entrance in 25 (71%) patients. At the same time, the ultrasonic examination discovered the pathology only in 7 patients (20%). EPST was performed in 20 patients of 25. The dissection of the major pancreatitis duct entrance was carried out in 16 of them; the dissection of the additional pancreatic duct was performed in 1 patient; the external pancreatic duct drainage was conducted in 5 patients; the additional pancreatic duct stenting was carried out in 1 patient. Fifteen patients (75%) felt better immediately upon the surgery. Ten patients were followed-up from 2 months to 3 years; steady amelioration was observed in 7 of them. There were complications in the form of acute pancreatitis in 3 patients after ERCPG and in 2 patients after endoscopic surgeries. There were no other complications or fatalities. For patients with the painful form of chronic pancreatitis, ERCPG is an informative and relatively safe technique enabling to discover the stenosis of the common bile duct entrance and/or main pancreatic duct entrance in 71% of cases. Endoscopic surgeries make it possible to produce an immediate positive result in 75% of cases.

Adult↗
PubMed1997

[The morphometric and immunohistochemical indices of the gastric and duodenal mucosa in the dynamic treatment of erosive gastroduodenitis in those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station in the follow-up period].

62 Chernobyl wreckers with erosive gastroduodenitis (50 cases) and ulcer (12 cases) were admitted to hospital where they received standard drugs and local He-Ne laser treatment of erosions and ulcer located in the antral stomach and duodenal bulb. Histological, bacterioscopic, morphometric and immunohistochemical examinations have identified chronic inflammation and disturbance of local immunity. After treatment epithelialization of erosions was not accompanied by normalization of morphometric and immunohistochemical parameters. This suggests a high risk of recurrences.

Adult↗
PubMed1994

[The characteristics of gastroduodenal pathology in the workers of a plant for plastic construction materials].

Out of 162 workers exposed to chemicals in the manufacture of construction plastics an outpatient and inpatient examination revealed gastrointestinal problems in 84.3%, vegetative nervous disorders in 62.6% of the examinees. In a random sample of 47 workers high acid production occurred in 63.3% and erosions, ulcers, cicatrices in the stomach and duodenum in 45.2% of them. No HLA genetic predisposition to duodenal ulcer was reported. Histological findings on gastroduodenal mucosa biopsies were indicative of the dystrophy in the chief and lining cells of the gastric glands, epithelium and stroma with formation of the dark cells. The authors insist on consideration of the above facts in examination and treatment of workers exposed to chemicals at construction plastics plants.

Adult↗
PubMed1987

[Removal of foreign bodies from the upper segment of the digestive tract using an endoscope].

The work presents data of the endoscopic diagnostics and treatment of 73 patients with foreign bodies in the upper part of the digestive tract (93 objects). High efficiency and little traumatism of removals of the foreign bodies from the upper parts of the digestive tract was achieved due to using a rational tactic of curative endoscopy consisting in using different models of modern fibroendoscopes and instrumental devices.

Adolescent↗
PubMed1987

[Role of current large-film fluorography in the improved diagnosis of gastric polyps in mass screening of the population].

The paper is concerned with a study of present-day potentialities for improving the diagnosis of stomach polyps. As the main diagnostic method the authors proposed gastric LFF with subsequent (as per indications) endoscopic examination of persons at high risk of development of the above pathology. Proceeding from an analysis of 110 cases of stomach polyps diagnosed at examination of over 11000 persons at high risk of developing stomach tumors, the authors emphasized a high efficacy of the proposed methods to find a solution to the problem of improving polyp diagnosis and issued their recommendations for their introduction into practice.

Adult↗
PubMed1984

Purified glucocorticoid-receptor complexes from rat liver cytosol preferentially bind in vitro to a homologous DNA fraction whose transcription is activated by cortisol.

The in vitro binding of 2000-fold purified rat liver glucocorticoid-receptor complexes to functionally differing homologous DNA fractions has been studied. The effectiveness of receptor binding to the transcriptionally active DNA, isolated from rat liver 4 h after cortisol administration, increased by 1.6-1.8-fold with simultaneous reduction in receptor affinity for the hardly extractable DNA fraction. The analogous DNA fractions from control animals did not differ in ability to bind the receptor. This suggests that sites of high affinity for the receptor are directly involved in the in vivo process of hormonal transcription activation.

Animals↗