["Military Medicine and Unit Care in the Theater of War in Bulgaria and in the Rear of the Field Army in 1877--1878" by N. I. Pirogov (on the centenary of its publication)].
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Biomedical subjects
Publications and source records attributed to G A Rusanov.
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In the experiments on 20 dogs with the left-side pulmonectomy it has been shown that the removal of one lung results in a progressive rise of the pulmonary circulation blood pressure which, in turn, causes some changes in the structure of the lung and of its function in the lipid metabolism.
A model of acute respiratory insufficiency ARI was created in the experiments on 16 dogs by means of a valvular device furnishing a free inhalation and a limited expiration. The diaphragmatic oxigenator devised in VNIIP with an armoured diaphragm of "Sigma"--type was switched on at the height of ARI. 3 hours' perfusion corrected successfully the manifestation of hypercapnic hypoxia. The pulmonary function restored after the experiment.
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The dynamics of acute lung edema development caused by injection of oleic acid into the right heart chambers was traced experimentally on dogs by means of impedance plethysmography. The most of information was collected with the help of electrodes applied to the chest. The development of acute lung edema was followed by decrease of the impedance respiratory undulations and by changes in their characteristics.
The response of the pulmonary tissue in a continuous stay of foreign bodies in the lung is characterized by chronic inflammation of the pulmonary tissue, deformation of the bronchial tree, atrophic, hyperplastic and dystrophic changes in the ciliated epithelium and its metaplastic degeneration into multitratum squamous epithelium. Chronic inflammation of the lung would develop mainly in bronchial injury with a foreign body or in impaired bronchial patency. In localization of metallic foreign bodies extrabronchially their incapsulation usually occurs.
In experiments on 50 dogs with toxic acute edema of the lung, induced with intravenous injection of 0.1% silver nitrate, the authors have studied the efficacy of accessory artificial circulation and "conservative" therapy. During the perfusion a discharge of the right portions, adequate extracorporeal gas metabolism, normalization of blood gas and acid-base balance were noted; an intensity of pulmonary edema is descreased. An intensive therapy for pulmonary edema was found to be more effective in association of "conservative" treatment with venoarterial perfusion and blood oxygenation.