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Biomedical subjects

G A Ryzhak

Publications and source records attributed to G A Ryzhak.

11 recordsLinked to original sources
PubMed2006

[The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats].

The synthetic peptides--cardiogen, bronchogen, prostamax and pancragen were used to investigate their effect on organotypic tissue culture of explants from heart, lungs, prostatic gland and pancreas of young (3-week old) and aged (18-month old) rats. The peptide effective concentration of 0.05 ng/ml showed a stimulating effect in appropriate tissue cultures as compared to the control explants in all groups of rats. So these bioregulatory peptides can be used in clinic practice for the stimulation of reparative processes in the appropriate tissues while ageing.

Aging↗
PubMed2006

[Effect of vilon on neuroendocrine status and sexual function of old male rats].

The hypogonadal status of hemigonadectomised male rats has been choseh as a model of age-related sexual function decline in animals. The effect of dipeptide Vilon on parameters of sexual function and neuroendocrine status was studied. The results showed that regular introduction of Vilon in a dose of 50 microg per rat activates sexual function in old male rats. The obtained data confirm that Vilon significantly affects neuroendocrine status of animals, as well as the level of LH, prolactin and ACTH and changes the content of neurotransmitters in hypothalamus. We consider the changes in sexual function caused by Vilon not relate to change in one parameter only, but are mediated by a set of neuroendocrine and neuromediatorial factors. Significant decrease in prolactin content in blood is worthy of notice, as age-related hypersecretion of this hormone is one of the main factors leading to age-related sexual function decline.

Adrenocorticotropic Hormone↗
PubMed2006

[Ultrasonic diagnostics of mediointimal hyperplasia as a predictor of atherosclerosis in old people].

The aim of the study was estimation of mediointimal hyperplasia of carotid artery for diagnosis of atherosclerosis in old people. 168 patients (94 male and 74 female) were in ultrasound investigation (Aloka 1100 in B-mode) of carotid, femoral arteries and abdominal aorta. Age 60-99 years old, mean 68.3. High level of blood cholesterin check in 41.46% patients. Low dencity lipoprotein mean 4.42 +/- 0.23 mmol/l, triglicerid 1.71 +/- 0.12 mmol/l, much more informative was mediointimal hyperplasia of posterior wall of carotid artery (regression rate r = 1.93). Ultrasound estimation of mediointimal hyperplasia of carotid artery is a safe, not expensive and informative method for diagnosis in screening of atherosclerosis in old people.

Aged↗
PubMed2006

[Effect of thymomimetic vilon on blood coagulation system and fibrinolisis in diabetes mellitus type 1 patients of different age].

It was revealed that patients suffering from the diabetes mellitus type 1 (DM-1) on the stage of destabilization report accelerated blood coagulability, decreased content of natural anticoagulators (antithrombin III and protein C), increased concentration of fibrogene and soluble fibrinmonomer complexes and reduced fibrinolysis. The obtained data testify the development of chronic form of DIC syndrome, moreover there is a correlation between the age of the patient, the severity of the disease, insulin dose, presence and severity of the complications on the one hand and the intensity of DIC syndrome on the other hand. Generally accepted treatment of the DM-1 patients doesn't exert considerable effect on the processes of intravascular blood coagulation. Meanwhile administration of thymomimetic Vilon (Lys-Glu) in these patients significantly reduces or even totally diminishes DIC syndrome. In elderly patients with severe form of the disease the effect of Vilon on coagulative hemostasis and blood fibrinolytic activity is less pronounced.

Adolescent↗
PubMed2005

[Correction of age-related skin changes by methods of cellular and bioregulation therapy].

In the recent years the development of methods of skin revitalization (remodeling)--i.e. of its restoration after damage of any nature (including aging)--attracted the attention of not only cosmetologists and dermatologists, but also of endocrinologists, physiotherapists, surgeons and geriatrists. The skin grows old together with the whole organism, and it is impossible to deter this process only in the skin. Nowadays a series of methods is offered in the esthetic medicine, using embryonic cells, regulatory peptides and placenta suspensions to influence the aging processes both in the skin itself and in the whole organism. This adds to life quality improvement and provides for social adaptation of elderly people.

Humans↗
PubMed2005

[Peptide bioregulator efficacy in the correction of reduced thyroid gland function in the residents of Magadan Region].

Thyroid gland pathology is one of the most widespread diseases. Age is the main risk factor in the development of hypothyroid states, alongside with biogeochemical and climatic adverse factors of the environment. Disturbed hormonal status of the organism affects the quality of life in patients with subclinical and manifested hypothyroidism forms, especially in old age, and requires adequate correction methods. In this connection Thyramin bioregulator is noteworthy, exerting tissue specific effect on thyroid gland cells and enabling the restoration of the disturbed thyroid tissue function.

Adult↗
PubMed2005

[Application of peptide bioregulator in complex treatment of elderly cancer patients].

Improvement of elderly cancer patients' treatment is an acute issue in oncology. The results of stage III rectal and colon cancer complex treatment are far from being satisfactory in this category of patients. In this connection the search for new adjuvant drugs supplementing radio and chemotherapy is urgent. The article describes pioneer experience in complex radical treatment of elderly cancer patients with immunomodulator Vilon included into the scheme of treatment. The obtained preliminary results of investigation suggest recommendation of Vilon application to increase 2-year survival of patients, prevention of post-operative complications, remote complications, recurrences and tumor dissemination, as well as the improvement of the quality of life after employment of aggressive methods of treatment.

Adult↗
PubMed2003

Study of protein components of natural peptide regulators.

Special attention should be given to the safety of drugs prepared from animal products. Industrial production of cytomedines and cytamines includes treatment of organs and tissues from young animals. Studies of preparations by methods recommended by the World Health Organization indicate that this technology guarantees the absence of infectious agents, protooncogenes, nucleic acids, and prion proteins.

Animals↗
PubMed1987

[Immunoenzyme method of determining thymus polypeptide factor].

A rapid indirect enzyme immunoassay technique for the determination of thymalin, a polypeptide thymus factor, with sensitivity equal to 1.5 X 10(-8) mol/l has been developed. The accuracy of determinations, measured by the variation factor, has proved to be 5-10% in the interassay, 10-15% in the interassay, the reliability in the opening test being 5%. The assay takes 4.5-5 hours.

Adjuvants, Immunologic↗
PubMed1985

[Isolation and evaluation of the specificity of an antiserum to the thymic polypeptide factor].

The specificity of antisera, obtained by the immunization of rabbits with the conjugated antigenic preparations of the thymic factor, have been evaluated by the method of immunochemical analysis. To carry out the comparative study, polypeptides isolated from the pineal body, cortex and white matter of the brain, Thy-1 antigen from the cerebral cortex and insulin have been used. The polypeptides of the thymus and the brain have been found to differ in their amino acid composition and molecular weight. The thymic factor possesses specific antigenic determinants which are absent in the tested preparations of cerebral polypeptides and insulin. The rabbit antisera obtained in this investigation are highly specific and can be used for the immunochemical determination of the thymic factor in the blood and other biological fluids.

Adjuvants, Immunologic↗