The experiment on 71 non-inbred white pregnant rats, 316 fetuses and placentas, 323 first progeny in experimental chronic impairment of uteroplacental circulation in females with pregnancy in the ploid period has found that decimetric waves (DW) in a weak heat dose (40 mW/cm2) prevents hypotrophy and disorders of fetal and placental development. Also, DW accelerate formation of motorsensory reflexes in the progeny in an early neonatal period and normalize their behavioral reactions at a mature age. The findings may serve experimental-theoretical grounds for application of weak heat DW radiation in obstetric practice in various general and regional hemocirculation.

Animals↗

PubMedDate not supplied

[The use of the perfused rat heart as a model for selecting antihypoxic compounds].

The test system for selection of antihypoxic compounds was developed and approved on the basis of the model of the perfused rat heart. It was found that the hypoxic state of the moderate degree of severity simulated on the myocardium is optimal for the assessment of the studied antihypoxic compounds. Taking into consideration the fact that at the early stages of hypoxia the electron transport is disordered at the level of the first enzymatic complex of the respiration chain, the protective actions of the agents (menadione and hydroquinone) being able of shunting the respiration chain to bypass the damaged area were studied. It was found that under hypoxia these compounds improve the energy-dependent contractile properties of the myocardium, that is, show up the antihypoxic effects.

Animals↗

PubMedDate not supplied

[Effect of fenibut and seduxen on fetal development in the second half of pregnancy].

In experiments on rats it was found that fenibut (50 mg/kg, 1/20 of LD50) during a single and repeated administration in the fetus period of pregnancy does not exert any negative effect on the maternal organism, the growth and development of the fetus. Seduxen administered in a dose of 50 mg/kg (1/80 of LD50) alone and in combination with fenibut was shown to decrease the female body weight gain and to disturb the fetus development. Following a single administration on the 17th day of pregnancy, the effect was poorly pronounced.

Animals↗

PubMedDate not supplied

[Analysis of the damaging action of different doses of nicotine on the female germ cells of rat fetuses].

The conducted studies have shown the gametotropic dose-dependent nicotine effect revealed both at the light-optic and ultrastructural levels. The revealed disturbances in oocytes may be regarded as a nonspecific response of the sex cells which is observed mainly in damage of the membrane oocyte components and specific (for sex cells) structure, a synaptonemal complex. Disturbances in the somatic ovary cells manifest only with a high nicotine dose.

Animals↗

PubMedDate not supplied

[Postnatal development of rat progeny after antenatal nicotine exposure].

The authors studied the effect of a chemically pure nicotine on the development of the first-generation progeny after subcutaneous injection of the drug into female rats throughout the entire pregnancy. The drug was injected daily with a four-hour interval, the total doses being 5; 1,5 and 0.4 mg/kg (1/5, 1/20 and 1/70 of the LD50). Following nicotine treatment in doses of 5 and 1.5 mg/kg the survival rate and body mass of the progeny were found to be lowered. The disorders identified in the functions of the nervous system (behavioral reactions) and cardiovascular system (blood pressure, heart rate) were ascertained to be dependent on the drug dose and sex of experimental animals.

Animals↗

PubMedDate not supplied

[Characteristics of the effect of nicotine on the mother-fetus system in exposure over the course of the entire pregnancy].

Experiments on Wistar rats were made to study the effects of nicotine administered in doses of 0.4, 1.5, and 5 mg/kg (1/70, 1/20 and 1/5 of the LD50) on the functional state of the mother's body and embryogenesis under exposure throughout the entire pregnancy. The mother demonstrated abnormalities of nervous and cardiovascular functions, which were dose-dependent. Nicotine was shown to have an adverse effect on the formation of the cardiovascular system in embryos and ossification in the bone skeleton. The cardiovascular system tended towards an "organ to organ" injury within the mother-embryo system.

Animals↗

PubMedDate not supplied

[The transplacental transit and action of ceftazidime on the fetus in an experiment on animals at different times of the pregnancy].

The experiments were conducted on pregnant albino rats to study the transplacental transit of ceftazidime (Fortum) to the fetus on days 14 and 21 of pregnancy after a single intramuscular injection of 100 mg/kg. The antibiotic transition was 5.23, and 51.94% on days 14 and 21, respectively. The total toxic and embryotoxic effects of ceftazidime were studied in pregnant albino rats given intramuscular injections of 100 and 500 mg/kg/day on days 9-20 of pregnancy. Ceftazidime was found to have neither negative effects on the maternal body and nor embryotoxic and teratogenic properties.

Abnormalities, Drug-Induced↗

PubMedDate not supplied

[The effect of antenatal nicotine exposure on the male germ cells in Wistar rats].

Chemically pure nicotine in dose 0.4, 1.5 and 5.0 mg/kg bw were percutaneously injected into Wistar rats during 1-20 (I) and 1-8 days (II) of pregnancy. The gametotoxic effect of nicotine in two-month males from offspring of the first generation (F1) was observed in disturbance of differentiation dynamics of spermatocytes at the stage of preleptotene and spermatids of the seventh developmental stage. The suggested quantitative analysis of disturbance in the behaviour of the meiotic chromosomes in metaphase I and II and anatelophase I and II has revealed that nicotine introduction in the period of isolation and migration of the primary sex cells into embryo gonads (2nd series) induces an increase in the level of pathological maturation divisions in the male offspring.

Animals↗

PubMedDate not supplied

[The protective action of limontar in pregnant animals with acute hypoxic hypoxia].

A comparative study of individual resistance of rats to acute hypoxic hypoxia was performed. It was shown that individual resistance of the organism to hypoxia significantly decreases in the course of pregnancy. Limontar is shown to be active antihypoxant. Limontar administered during the last third of pregnancy stimulates protective-adaptive reactions in the females, thus increasing their resistance to hypoxia.

Acute Disease↗

PubMedDate not supplied

[The corrective properties of glycine in alcoholic intoxication in the fetal period of pregnancy].

Natural metabolite glycine administered per os to rats in the fetus period of pregnancy in a dose of 1 mg/kg was found to exert a corrective action with respect to the toxic effect of ethanol in the mother-fetus system. Glycine prevents loss in the body weight, normalizes functional state of the nervous system and metabolic disorders in the maternal organism, improve the redox processes in the lymphocytes changed under alcoholization, and protect the fetus both on the metabolic and microstructural levels.

Alcoholic Intoxication↗