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Biomedical subjects

G A Shifrin

Publications and source records attributed to G A Shifrin.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[The luminescence of blood leukocytes, stained with the fluorochrome acridine orange, from surgical patients in the dynamics of emotional, anesthesiological and surgical stress].

Luminescence of blood leukocytes of surgical patients during treatment was studied using orange acridine. Luminescence intensity at 640 nm wave length (I640) was the most informative. It characterized amount of single-stranded nucleic acids, synthesized in cell due to previous activation of protein-synthesizing system and hence cell functional activity, while in lymphocytes these changes exceeded by duration and amplitude those in neutrophils. During premedication (emotional stress) I640 was minimal, during anesthetization it developed, and sharply raised during traumatic period of surgery and after it, as reflection of immune system participation in reparative regeneration.

Acridine Orange↗
PubMedDate not supplied

[Pathophysiologic characteristics of the reactive toxic stage of acute suppurative peritonitis and ways to enhance the effectiveness of intensive therapy].

The oxygen regimen, circulation, and metabolism were studied in 95 patients in the reactive-toxic stage of diffuse purulent peritonitis. The results of cluster analysis made it possible to determine the clinical and pathophysiological features of the phases of the disease. The phase of compensation was characterized by disorders of mass exchange of plasma water which led to increased index of transcapillary exchange and increased excess of lactate. These parameters of tissue metabolism were grouped into one cluster together with the oxygen regimen value and mean arterial pressure. The other cluster was formed of the values of oxygen consumption and the values of oxygen systemic and vascular tissue transport and the hemodynamic parameters. In the phase of decompensation the homeostasis parameters were grouped into another 2 clusters. The first contained the indices of transcapillary exchange of oxygen and water, the other--those of the intensity of blood oxygen transport function and metabolism. Surgical treatment and inclusion of the sympatholytic agent ornid and the beta-adrenergic agonist alupent in the complex of intensive therapy from the stages of preoperative and anesthesiological management brought homeostasis to a level characteristic of the phase of compensation, as a result of which fatal outcomes were absolutely excluded.

Acute Disease↗
PubMedDate not supplied

[An infusion-transfusion calculator].

The infusion-transfusion calculator is currently used in intensive care units to compute hemodynamic parameters and volumes of infusion-transfusion media. The system is based on the microcalculator (Formula: see text) and the programmed read-only memory incorporating the programs to compute parameters of interest.

Blood Transfusion↗