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Biomedical subjects

G A Sinaĭko

Publications and source records attributed to G A Sinaĭko.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Antigen e and its antibodies in acute serum hepatitis and in persons with a prolonged HBs-antigenemia].

The gel precipitation test was used for examinations of 280 HBsAg-positive patients with jaundiced serum hepatitis and 182 subjects with long-term HBs-antigenemia and various degrees of activity of the pathologic process in the liver, in a coded study. Among the latter, the e-antigen was found in 26.9%, that is twice as frequently than in patients with acute serum hepatitis (14.3%). Particularly frequently (31.1 and 45.2%) the e-antigen was found in children and adults who were assumed to have been the source of SH infection, as well as in infants infected from their mothers during delivery or soon after birth. A certain correlation was found between the rate of detection of the e-antigen and the presence of biochemical changes indicating liver function disorders. Thus, the e-antigen may be a marker of a higher infectivity of the serum and indicate a certain activity of the pathological process. Antibodies to the e-antigen were more frequently found in older age groups and in the absence of biochemical changes in the serum. The e-antigen and antibody to it were detected with similar frequency in infections with subtypes ay and ad of the HBs-antigen.

Acute Disease↗
PubMedDate not supplied

[Morphological makeup of the structures containing HBsAg in the blood of acute and chronic serum hepatitis patients].

Immune electron microscopy was used to examine the morphological composition of HBsAg-containing structures in 20 patients with acute serum hepatitis (ASH) and severe accompanying disease in whom HBsAg had been detected by the gel precipitation test for a long time, and in 7 patients with HBsAg-positive chronic active hepatitis (CAH) developing after ASH. Small spherical particles were the predominant form of HBsAg-containing structures in all the sera. Among ASH patients, a significant number of tubular forms and Dane particles were detected mainly in patients with severe accompanying diseases. No correlation between the appearance of a large number of Dane particles and tubural forms and the severity of the disease in ASH was established. In CAH, tubular forms and Dane particles in large numbers were found only in patients with long periods after ASH. Large numbers of Dane particles in all the examined patients were combined with a large number of tubular forms.

Acute Disease↗