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Biomedical subjects

G A Szekely

Publications and source records attributed to G A Szekely.

8 recordsLinked to original sources
PubMed1987

Platelet [3H]imipramine binding in autism and schizophrenia.

[3H]Imipramine binding to platelet membranes was evaluated in ten autistics, eight schizophrenics and seven normal controls. The schizophrenics and eight out of the ten autistics were maintained on chronic neuroleptic treatment. Diagnosis of autism and schizophrenia was established according to the DSM-III criteria. No significant difference in the maximal binding capacity of [3H]imipramine (Bmax) and Kd values could be found among the three groups. It seems that the imipramine binding site is intact both in autism and schizophrenia.

Adolescent↗
PubMed1982

Abnormal immune response to brain tissue antigen in the syndrome of autism.

Cell-mediated immune response to human myelin basic protein was studied by the macrophage migration inhibition factor test in 17 autistic patients and a control group of 11 patients suffering from other mental diseases included in the differential diagnosis of the syndrome of autism. Of the 17 autistic patients, 13 demonstrated inhibition of macrophage migration, whereas none of the nonautistic patients showed such a response. The results indicate the existence of a cell-mediated immune response to brain tissue in the syndrome of autism.

Adolescent↗
PubMed1980

Platelet uptake of serotonin in psychotic children.

Platelet serotonin (5-HT) uptake was assayed in ten long-term hospitalized children subdivided into two diagnostic groups "autistic" and "other psychotic". Weekly blood samples were taken from these children over a period of 6-7 weeks and serotonin uptake was determined. Constant and significant uptake values (13.28 +/- 2.0 pmol serotonin/10(8) platelets/5 min for autistics and 9.59 +/- 1.58 pmol serotonin/10(8) platelets/5 min for other psychotics) were obtained. There was no correlation with drug treatment or with behavioral fluctuations in individual children. Three weekly uptake assays performed on six parents suggest the possible importance of genetic factors in these diseases. Biochemical-kinetic methodological problems of platelet 5-HT assessment are discussed.

Adolescent↗