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Biomedical subjects

G A Vakulenko

Publications and source records attributed to G A Vakulenko.

6 recordsLinked to original sources
PubMed2000

[The treatment of the initial stage of cervical cancer].

The analysis of the author's own experience and of relevant published literature suggest that it is expedient to further elaborate methods for treatment of incipient forms of uterine cervix cancer aimed to preserve the genital organs in women, especially in those at childbearing age. Worthy of mention in this respect is the progress made by the Kiev City Oncological Centre. In choosing a treatment option, it is necessary that etiopathogenic risk factors for development of cancer of the uterine cervix by analyzed and taken account of.

Adult↗
PubMedDate not supplied

[Etiotropic treatment of patients with early uterine carcinoma as a basis for prevention of relapses and complications].

In this paper, consideration is given to the role that etiological and pathogenetic factors have in the development of malignant tumours. Prevention of possible recurrencies and complications in patients with incipient forms of hysterocarcinoma warrant etiotropic treatment which has been shown to be effective and essential for the object to succeed in.

4-Quinolones↗
PubMedDate not supplied

[The cytological characteristics of the cells of the multilayer squamous epithelium of the cervix uteri in relation to the association of the pathological processes with the human papilloma virus].

An analysis of cytological material in benign (160 observations) and dysplastic (101 observations) processes, as well as in cervix outset cancer (38 observations) with the aim of search for koilocytic atypia markers in the cells, existing due to HPV infection, has been carried out. High association degree of the virus infection with the material under study has been ascertained. It was found out that the increase of koilocytosis phenotypic markers expression rate is a reliable criterion of cervix uteri pathologic processes progression. The signs of permanent koilocytic atypia in women with dysplasia should be considered as prognostic marker of malignant transformation of cervix uteri epithelium.

Cervix Uteri↗
PubMedDate not supplied

[The morphological characteristics of a papillomavirus infection in the epithelial tissue of the cervix uteri in comparison with the data from the molecular biological identification of specific HPV DNA sequences].

Summarized cytomorphologic, molecular-biological data and the analysis results of cervix uteri multilayer squamous epithelium cells mitotic regime in benign (104 observations) and dysplastic (101 observations) processes, including 6/11 and 16/18 types DNA HPV, are presented in the paper. It has been shown that the use of HPV-infection morphologic markers as compared with cell mitotic activity and with in situ hybridization results allows one to determine the obvious virus role in the induction of flat, acute and papillar condylomas, as well as of cervix uteri dysplastic processes. To ascertain the prognosis of development of dysplasia associated with HPV DNA of 6/11 and 6/18 types, the increase of mitosis pathological forms and of their arrangement zones in epithelium layer parallel with gravity increase of three-group, multipolar and K mitosis should be considered a reliable marker of high oncogenic risk.

Biomarkers↗