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G A Zakharov

Publications and source records attributed to G A Zakharov.

17 recordsLinked to original sources
PubMed2004

[Effect of adaptation to high altitude on the state of electric cardiac stability and lipid peroxidation during catecholamine cardionecrosis in rats].

The change of electric cardiac stability parameters and LP in catecholamine cardio necrosis in rats simulated by prolonged injection of increasing doses of noradrenaline was studied in this work. It was established that noradrenaline injection in low-altitude (760 m) and high-altitude (3200 m) is accompanied by hypertrophy, microcirculation disturbances, ischemia and cardiomyocytes necrosis, ECS decrease, LP activation and decrease of enzymatic activity of antioxidant defense. ECS of animals adapted to high-altitude decreased less and their LP processes were more active with preservation of enzymatic activity of antioxidant defense.

Adaptation, Physiological↗
PubMed1999

[Changes in hypoxic resistance and conditional avoidance reflex during hypobaric adaptation on the "flatland" and in mountains].

White rats--males with mass 200-250 g were exposed ipobaroadaptation (rise on 12,000 m with an exposition 5 minutes) with periodic testing them on gipocsition stability. After shaping in the result of gipobaroadaptation stressostability, that it was judged in 2-3 times enlarging of reserve time, rats produced conditional reflexes at active avoid (CRAA) as on plain area (760 m) so in high-mountainous (2500 m). It is observed that gipobaroadaptation increases gipocsition stability and accelerates the CRAA shaping on plain area and in mountains. The maximum effect of gipocsition stahility increasing, CRAA consolidation and perfecting of efferention synthesis at high-mountainous gipobaroadaptation rats is more significant, thah at "flat." gipobaroadaptation has important protective significance for function of a brain, decreasing its sensibility to lock of oxygen and fixing maximum adaptive responses.

Adaptation, Physiological↗
PubMed1996

[Effects of high altitude on changes in blood coagulation in rats during prolonged administration of noradrenaline].

Alterations of the plasma factors of hemocoagulation produced by injection of norepinephrine (NE) at progressively increasing doses over 14 days (the total dose ran 35 mg/kg of body mass) were studied in three groups of rats, i.e., animals bred at the low altitude of 760 m in Bishkek (group I), animals in-adapted (group II) and adapted to high altitude of the Tuya-Ashu pass (3200 m, Group III). By the 7th day of NE injection group-I developed a moderate hypercoagulation which persisted till the end of experiment. In adapted animals the high altitude exposure initiated hypocoagulation shifts which then gave place to hypercoagulation ones due to elevated activity of the procoagulant component of homeostasis. Maximally pronounced hypercoagulation charges were recorded in in-adapted rats (group II) and interpreted as a stress-reaction to natural hypoxia augmented by the stress-agent (NE). High altitude revealed greater defense-adaptive potential of the homeostatic system manifested as enhancement of the anticoagulation blood activity, e.g., increased ability to inactivate thromboplastin and thrombin, and fibrinolysis.

Adaptation, Physiological↗
PubMed1995

[Effects of high altitude on the morphofunctional state of mast cells of the subcutaneous connective tissue during physical exercise].

The Wistar male rats were exposed to submaximum exercise (by swimming for 5 hours) at a high altitude (HA) environment (the Tuya-Ashu Pass, 3200 m above sea level). Sampling was done on Days 1, 15, 30 and 45 of animal living in the mountains. The control group of animals was examined in the lowlands regions (Bishkek, 760 m above sea level). It is indicated that during exercises performed in the mountain environments the mast cell reaction judging from the morphologic manifestations is similar to that observed during adaptation without exercises but in this case the cell restoration occurs more rapidly. The study of the time-course of changes in the morphofunctional state of mast cells in both groups of animals allows one to conclude that such an early significant degranulation and mass degradation at early times are conditioned not only by stressful reaction of the body but also by the effects of HA hypoxia and exercise stimulating their subsequent accelerated proliferation due to migration of juvenile forms from the region of cambial reserve to the skin surface compartments.

Adaptation, Physiological↗
PubMed1993

[Features of mast cell status and blood coagulation during long-term administration of noradrenaline in mountain dogs].

The total number of mast cells and their forms is increased, degranulation is weakly marked in dogs permanent of medium altitude (1650 m) in comparison with low altitude dogs (760 m) after the long-term NA injections addition with reaction similarities some differences were observed. The total number of mast cells is decreased less considerably, the number of average forms of maturity and to some extent the number of the third power degranulation are increased in altitude dogs. The decrease of the high altitude adaptive heparin level is observed, the activity of fibrinolytic system is marked facilitating the prevention of microcirculatory disturbances. Thus, mast cells and hemocoagulation systems of altitude are more resistant to the long-term noradrenaline loadings.

Altitude↗
PubMed1989

[Mast cell and blood coagulation functions during prolonged noradrenaline administration].

During the long term noradrenaline injection (0.56 microgram/kg/min-2 hours during six days) the number of connective tissue mast cells decreases in dogs. Mature cells disappears and the percentage of young forms increases. Marked degranulation develops. 5-10 cell groups and chains are formed. The increase of free heparin level and the activation of anticoagulant unit hemostasis correspond to these changes. It is due to mast cells discharge of biologically active heparin which is an unspecific adaptogen.

Animals↗
PubMedDate not supplied

[Clinico-immunological characteristics of people who worked within the 30-kilometer zone of the accident at the Chernobyl Atomic Power Plant 4 years after the accident].

Clinical examination with immune status assessment of more than 300 healthy persons, who worked in 30-km Chernobyl NPP zone four years after the accident was carried out. The clinical characters of immune deficiency were detected in 6.67% of examined persons and appeared as repeated respiratory diseases. Significant increase in mean level of leukocytes and lymphocytes was revealed. Activation of T-helper link of cell immunity was determined by increase of CD4+ cells in 35.2% of examined persons, that were lower than in people who took part in Chernobyl accident amelioration in 1986. Decrease in content of T-cells and B-cells was observed in 1/4 and 3/4 of persons correspondingly by rosette assays. No changes in serum immunoglobulins level was observed.

Adult↗