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Biomedical subjects

G Achten

Publications and source records attributed to G Achten.

At least 19 recordsLinked to original sources
PubMed1991

[Immunohistology of bullous autoimmune skin diseases].

Autoimmune bullous dermatoses undertake frequently oropharyngeal mucous membranes and the skin surface, either in succession or simultaneously. Actual observation technics by photon and electron microscopy, by immunofluorescence and immunohistochemistry (with specific antibodies) have allowed to differentiate more particularly pemphigus, bullous pemphigoid, cicatricial pemphigoid, acquired bullous epidermolysis, all autoimmune bullous affections.

Autoimmune Diseases↗
PubMed1991

Nails in light and electron microscopy.

The study and the diagnosis of nail disorders benefit from examination under light and electron microscopes. The alterations occurring in the matrix, bed, and hyponychium are comparable to those observed in the skin. Architectural and cellular alterations--loss of the cell's regular alignment, changes in stain affinity, parakeratosis, and changes in the intercellular spaces--are observed in the nail plate and subungual keratin. The intensity and singularities of these lesions are usually sufficient to orient the diagnosis from examination of the keratin alone. This microscopic examination is of particular interest in dealing with mycoses because it can specify the type of invasion of the keratin and avoid false-positive or false-negative results on culturing. Electron microscopy allows easy differentiation of melanin and ferric pigments.

Humans↗
PubMed1988

Dominant dystrophic epidermolysis bullosa of Cockayne-Touraine in father and son: clinical and ultrastructural similarities.

Dominant dystrophic epidermolysis bullosa of Cockayne-Touraine occurred in a father and his son. Clinically, the child presented evident blistering, while the father, despite of his work, where minimal skin traumata frequently occur, was rarely affected. Absent or rudimentary anchoring fibrils were seen in the normal-appearing skin of the father; this suggests that other factors may play a role in the dermolytic separation.

Actin Cytoskeleton↗
PubMed1988

Larva migrans of the oral mucosa.

A case of buccal larva migrans is presented. This rare peculiar localization is discussed. The different treatments are mentioned with special regard to the topical and systemic use of the thiabendazole.

Administration, Oral↗
PubMed1988

Nail changes in alopecia areata: light and electron microscopy.

Fragments of nail keratin removed with tweezers from patients suffering from alopecia areata were examined using light microscopy and electron microscopy. The results obtained from these two techniques show nail changes which are slits, cupuliform dips of the upper edge and parakeratosis, under light microscopy; vacuoles, depletion of keratin fibers, and electron-dense fibrillary deposits, under electron microscopy. These changes predominate in the nail plate with a maximum in the upper part while the subungual keratin is preserved. A serious disorder of the matrix keratinization is probably the source of this preferential localization. To determine whether it is a disorder of the keratin fibers themselves or rather of the interfilamentary matrix and especially of the filaggrin system will require further biochemical and immunological studies.

Alopecia Areata↗
PubMed1987

Onychomycosis.

Explore the source record for details and available documents.

Arthrodermataceae↗
PubMed1987

Cosmetic intolerance.

A study of cosmetic intolerance has been undertaken in 5202 patients tested for possible contact dermatitis. Each patient has been evaluated by medical history and patch testing. Intolerance to cosmetics involved only 5.9% of the total population tested. If other possible sources of allergens (medication, occupation, hobbies etc) are associated, this figure rises to 11.7%. The origin of the cosmetic intolerance is more often an allergy than irritation. Soaps and shampoos are the most important types of cosmetics responsible for adverse reactions. The principal allergens are the fragrances, preservatives, hair dyes and the patients' own products. In this last category, the specific allergen has not always been detected.

Adult↗
PubMed1987

[Atypical urticaria disclosing acute basophilic leukemia. Apropos of a case associated with hyperhistaminemia].

Acute basophilic leukaemia (ABL) is a rare disease characterized by high fever, anaemia and haemorrhagic diathesis. Its prognosis is somber and its response to therapy mediocre. Death is mainly due to cerebral or digestive hemorrhage and coronary disease. In a very small number of cases ABL, like all diseases accompanied by an increase in basophils, may be associated with hyperhistaminemia responsible for cutaneous and gastric symptoms.

Acute Disease↗
PubMed1985

Clinical and immunologic response to Isoprinosine in alopecia areata and alopecia universalis: association with autoantibodies.

Twenty patients with alopecia universalis, alopecia semiuniversalis and alopecia areata were studied for their immune parameters. Fourteen of them received an oral treatment with Isoprinosine, a synthetic immunomodulator. Ten patients showed the presence of several autoantibodies. No significant abnormalities in various T cell rosette markers were found, but T4/T8 ratios tended to be elevated. Erythrocyte antibody complement (EAC) rosettes were usually decreased. Treatment with Isoprinosine produced a clinical response, as judged by total or partial hair growth, in nine of the fourteen patients treated. It was striking to observe that seven of the nine responders had autoantibodies prior to treatment. These autoantibodies disappeared or decreased with Isoprinosine therapy. In contrast, only one of five nonresponders had serum autoantibodies. After treatment, both groups showed an increase in blood-active T rosettes. These results suggest that alopecia is a heterogeneous disease subdivided by the presence or absence of autoantibodies since clinical response was mainly obtained in patients presenting autoantibodies.

Adolescent↗
PubMed1985

[Comèl's ichthyosis linearis circumflexa: treatment with Ro 10-9359. Electron microscopic study].

The authors show the noteworthy efficacy of the aromatic retinoid Ro 10-9359 in the treatment of ichthyosis linearis circumflexa. The initial dose was 1 mg/kg daily; later on, the maintenance dose was 0.3 mg/kg daily. Ultrastructurally, transitional cells were observed between the granular and the horny layer. After treatment, large perinuclear pseudovacuoles appeared, as well as numerous microvilli.

Adult↗