Normal electron tunneling in ramp-type YBa2Cu3O7/PrBa2Cu3O7/YBa2Cu3O7 junctions prepared by laser ablation.
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Journal Article↗
Biomedical subjects
G Adrian
Publications and source records attributed to G Adrian.
[Cerebrospinal fluid, especially cell findings, in subarachnoid hemorrhage].
Liquor samples (n = 303 each from the Neurological Department of the Wilhelm Pieck University Rostock, GDR and the Neurological Hospital of the Pommeranian Medical Academy, Szczecin, Poland) collected from patients following subarachnoid hemorrhage are used as a basis to present various findings for the, on the whole, characteristic hemorrhagic liquor syndrome. The differential liquor cell picture (sedimentation after Sayk) is important for determining the time of the hemorrhage and the post-hemorrhage phase and for identifying recidivating hemorrhage and complications, including hemorrhagic meningoencephalitis (lympho-plasmocytic cells), post-traumatic states (activated macrophage and storage function) and blastomatous infiltration (malignoma cells). Artificial blood contamination (easily recognisable immediately after puncture) leads to differences, with less granulocytosis and a few sparsely charged macrophages, a few days later; the same also applies to diseases stemming from the vessels and hematomas that are not in contact with the liquor space. Despite the introduction of diagnostic hardware, examination of the liquor a few days after subarachnoid hemorrhage is still important as a means of identifying recidivating hemorrhage and complications and, in particular, for differentiation from inlammatory diseases of the CNS.
Adult↗
[Combination treatment of malignant brain tumors. Results of initial experiences].
First experiences with the combined treatment of malignant gliomas (29 cases) are presented in connection with the results reported in literature. The cytostatic therapy has been carried out according to the modified Israel-Scheme of Heiss et al. Using the combined treatment (resection of tumor, radiotherapy and polychemotherapy) a prolongation of survival time to 55 till 80 weeks is noticeable. The patients observed in our study survived on an average 79,8 weeks (operation and chemotherapy) resp. 94,7 weeks (operation, radiotherapy and chemotherapy). Special problems of the cytostatic therapy of malignant brain tumors are considered, among others in relation to the blood-brain-barrier and the tumorcell-kinetics; a further optimation of therapy is necessary.
Adolescent↗
Entrapment of proteins in phosphatidylcholine vesicles.
The trapping efficiency of globular proteins in four different types of phosphatidylcholine vesicles was systematically studied. Vesicles were generated in a mixture of 125I-labeled proteins of various molecular weights. The trapped proteins were separated from untrapped proteins by gel filtration and ultrafiltration and subsequently analyzed by gel electrophoresis and autoradiography. Entrapment of proteins was demonstrated by their resistance to trypsin digestion. The relative amount of each entrapped protein species was then compared to that of the original protein solution. In multilamellar vesicles and large unilamellar vesicles, proteins of molecular weight up to 97 000 had the same trapping efficiency as sucrose. In small unilamellar vesicles generated by either sonication or ethanol injection, however, the relative trapping efficiency of protein decreased progressively as the molecular weight of the protein became greater. For example, the trapping efficiency of alpha-amylase (Mr 97 000) was only half of that for sucrose. The apparent decrease in trapping efficiency with the protein's molecular weight in small unilamellar vesicles canbe accounted for by the combination of the bound water layer at the vesicle's internal surface and the steric hindrance when protein is captured during vesicle formation.
Chymotrypsinogen↗