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Biomedical subjects

G Aktaş

Publications and source records attributed to G Aktaş.

4 recordsLinked to original sources
PubMed2005

HpSA fecoprevalence in patients suspected to have Helicobacter pylori infection in Istanbul, Turkey.

OBJECTIVE: This study aims to investigate the Helicobacter pylori antigen in the stool samples of patients suspected to have H. pylori infection. It also aims to determine the fecoprevalence in different age groups and to look for the relationship between the clinical symptoms seen in patients and the existence of H. pylori. Current information in Turkey is insufficient. METHODS: The Helicobacter pylori antigen was investigated in the stool samples of 445 patients of whom 148 were in the 2-15 year age group, 96 in the 16-30 year age group, 85 in the 31-40 year age group and 116 in the 41-48 year age group. The main clinical complaints of the patients (stomach pain, heart burn, indigestion, gas, nausea, vomiting, diarrhea, abdominal pain) were recorded. RESULTS: The Helicobacter pylori antigen was found in 36.6% (163/445) of the patients and in the statistical evaluation made for different age groups, a significant linear relationship was found between age and infection (chi2=14.77, p=0.002). CONCLUSION: It was found that stomach pain was seen at a higher rate in patients with H. pylori antigen compared to those without it. The difference was highly statistically significant (chi2=117.70, p<0.001, OR=20.36, 95% CI=10.56-39.27).

Adolescent↗
PubMed2004

The analgesic effect of morphine on postoperative pain in diabetic patients.

BACKGROUND: Many clinical and experimental studies have suggested that diabetes or hyperglycemia alter opioid responsiveness. However, little information is available on the effects of diabetes mellitus on opioid requirements in the postoperative period. METHODS: Sixty-four patients scheduled for elective, total abdominal hysterectomy were included into this prospective study to evaluate the effect of diabetes mellitus on morphine requirement in the postoperative period. A loading dose of morphine (50 micro g kg(-1)) was administered in the perioperative period. Postoperative analgesia consisted of intravenous morphine-PCA. No analgesic other than morphine was allowed during the study. In cases of inadequate analgesia intravenous 1 mg of morphine was given as a rescue analgesic. Cumulative morphine consumption, pain scores and morphine-related adverse effects were recorded. RESULTS: A total of 60 patients were evaluated: Group D, 30; and Group ND, 30. Patients in Group D received more morphine than those in Group ND (54.12 +/- 25.09 and 42.66 +/- 20.67, respectively). The difference in cumulative morphine consumption was higher in the first hour (P = 0.037) in diabetic patients and they required significantly more morphine in the last 24 h (P = 0.015). Postoperative pain scores were higher in the diabetic group. More patients in the diabetic group required rescue medication (26 vs. 19) and felt nauseous (25 vs. 14; P = 0.003). CONCLUSION: The findings of the study appear to support experimental and clinical impressions that the analgesic effect of morphine is attenuated in hyperglycemic conditions. Therefore, larger doses of morphine may be administered to diabetic patients for effective postoperative analgesia.

Adult↗
PubMed2001

Gender influence on jejunal migrating motor complex.

The role of gender and the menstrual cycle in small bowel motility has not been clearly elucidated. Jejunal motility was recorded with a nasojejunal catheter incorporating five solid-state pressure transducers in ambulatory menstruating women and men of comparable age over 24 h. All women were studied twice, in the early follicular (early-F) and midluteal (mid-L) phases of the menstrual cycle, verified by determining serum levels of gonadal steroids and gonadotropins. The propagation velocity of phase III was slow and the contraction amplitude was high in both menstrual cycle phases compared with men, and these parameters were correlated with serum estrogen levels in the mid-L phase. In the early-F phase, migrating motor complex (MMC) cycle duration during sleep was long compared with other groups and positively correlated with estrogen concentrations, whereas in the mid-L phase MMC cycle duration during sleep was negatively correlated with serum progesterone levels. In all groups, the frequency of phase III contractions was low and the intercontractile interval measured from pressure peak to peak was long during sleep compared with the awake state. Postprandial motility did not display gender difference in any parameter examined. The results demonstrate that the majority of patterns of motility are similar in menstruating women and men, whereas certain aspects of the MMC, most conspicuously propagation velocity and phase III contraction amplitude, differ. We have also documented circadian variation of phase III contraction frequency in both women and men.

Adult↗