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Biomedical subjects

G Alpert

Publications and source records attributed to G Alpert.

53 records · Page 3Linked to original sources
PubMed1983

Mucocutaneous lymph node syndrome (Kawasaki dIsease) in Israel. A review of 13 cases: is pseudomonas infection responsible?

In this report the clinical, laboratory and histopathological findings of 13 children with Mucocutaneous Lymph Node Syndrome (Kawasaki disease; MCLS) are reviewed. This is the first report of a series with a description of the clinical findings as well as pathological findings in patients from Israel. Pseudomonas infection appeared to be the underlying cause of both the clinical symptoms and the pathological changes of some (or all) cases of Kawasaki disease.

Adolescent↗
PubMed1980

Gastrointestinal manifestations of Niemann-Pick disease.

3 infants wih the acute neuronopathic form of Niemann-Pick disease had prominent gastrointestinal manifestations. These included chronic diarrhea, malnutrition, failure to thrive, radiologic intestinal abnormalities, xylose malabsorption, abnormal liver function, and infiltration of the liver, lamina propria and autonomic ganglia by lipid-laden cells. Possible pathogenetic mechanisms are discussed, and it is suggested that gastrointestinal disturbances play a larger part in the clinical manifestations of Niemann-Pick disease than is usually appreciated.

Digestive System↗
PubMedDate not supplied

Complications of infection with Epstein-Barr virus during childhood: a study of children admitted to the hospital.

We undertook a study of infection with Epstein-Barr virus (EBV) in order to ascertain the spectrum of complications from this disease. During a 6-year period, 51 children were admitted; review of the 50 available records confirmed the diagnosis of EBV infection in 48, 37 of whom had clinical infectious mononucleosis. The indications for admission were diagnostic evaluation in 14 (29%) children, airway obstruction in 12 (25%) children, dysphagia and dehydration in 11 (23%) children, airway obstruction and dehydration in 2 (4%) children, severe malaise in 2 (4%) children, pneumonia in 2 (4%) children, encephalitis in 2 (4%) children, Guillain-Barré syndrome in 1 (2%) child and unrelated conditions in 2 (4%) children. Additional complications developing during hospitalization included peritonsillar abscess, pancytopenia, pleural effusion, hepatitis and hyponatremia. We believe that infection with EBV has a higher morbidity in childhood than previously appreciated.

Adolescent↗
PubMedDate not supplied

The chloride-stimulated K(+)-secretion by insect midgut and its modification in the presence of osmotic gradients: a short-circuit current and noise-analysis study.

K(+)-secretion in the midgut of the larval moth, Manduca sexta, was studied by measuring the kinetics of the lumen-directed short-circuit current (Isc) and the conduction noise from basolateral K+ channel block by Ba2+. Hemolymph chloride as well as hypotonicity both stimulate this K+ current (IK). The kinetic nature of the stimulation is, however, different in each case. Analysis of blocker noise supports, to a large degree, the interpretation obtained from kinetics, namely: chloride ions do not act via changes in cell volume but influence ion turnover and channel number.

Animals↗
PubMedDate not supplied

Physiological assessment of the passive children's hood.

The physiological effect of the "passive children's hood" (PCH) was studied in 24 children: 8 toddlers (3-4.5 years old), 8 pre-school pupils (4.5-6 years) and 8 first- and second-grade pupils (6-8 years). This device consists of a children's gas mask and a transparent PVC (polyvinyl chloride plastic) covering (hood). Inspiratory CO2 and O2 (FiCO2 and FiO2, respectively), temperature and humidity were monitored at 10-min intervals while the children were occupied with sedentary activities (playing and watching TV) in a sealed room. Ambient temperature and relative humidity were approximately 27 degrees C and 75% respectively. In the PCH space the temperature was 2 degrees C higher and humidity was near saturation at the end of exposure. FiCO2 in 12 children exceeded 2%, which is the upper acceptable limit according to industrial standards. In four of them FiCO2 was greater than 4% and FiO2 less than 16%. Twenty-two children tolerated the PCH for 92 +/- 35 min (range 24-133 min) with no physiological complications. A significant correlation was found between childrens' age and tolerance time (r = 0.47, P less than 0.025). We conclude that children whose masks are not well adjusted may be exposed to rebreathing CO2-enriched air.

Age Factors↗