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Biomedical subjects

G Ando

Publications and source records attributed to G Ando.

4 recordsLinked to original sources

[Compression therapy in deep venous thrombosis].

External compression, both intermittent by pneumatic pumps and continuous by anelastic or elastic bandages and by graduate compression stockings, play a pivotal role in prophylaxis of Deep Venous Thrombosis (DVT). The use of external compression in DVT therapy and in prophylaxis of pulmonary embolism (PE) and of post-thrombotic syndrome has not been validated as well as in DVT prophylaxis. The pathophysiologic properties of the external compression and the most recent evidences about the early mobilization of the patients with DVT and about Low Molecular Weight Heparin (LMWH) therapy suggest the advantages of the external compression. The authors review the most important clinical investigations about early use of external compression in DVT joined with pharmacological therapy: the results have been the reduction of the growth of the thrombus, the reduction of PE ratio, the prevention of the post-thrombotic syndrome, the indirect improvement of the quality of life. Finally the authors confirm the recommendations about the use of physical therapy with early mobilization and external compression joined with LMWH anticoagulation in DVT.

Anticoagulants↗

Biological availability and pharmacokinetics of tinidazole after single and repeated doses.

Tinidazole was administered to healthy volunteers and serum concentrations were measured following single oral and intravenous doses and after repeated dosage at different dose levels. The elimination half-time was 12-13 h. Pharmacokinetics did not change with dose, route of administration or repeated dosage. The bioavailability of single oral doses ranged between 88 and 129% with a mean of 99%. Serum concentration curves tended to have double peaks or plateaus at about 4-6 h. 74% of the intravenous dose was eliminated from serum at 24 h, but only 19% was recovered in the urine, suggesting alternative ways of elimination. Excretion in the bile and a subsequent enterohepatic circulation may explain the variations in bioavailability and the shape of the serum concentration curves.

Adult↗