[Thrombosis prevention after hip arthroplasty].
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Biomedical subjects
Publications and source records attributed to G Andreassen.
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In November, 1993 the UN opened a Norwegian field hospital in Bosnia-Herzegovina. The hospital was handed over to the American IFOR forces in November, 1996. In the present study, we analyse the activities at the hospital and the results achieved by the Norwegian management. While under Norwegian supervision 2,593 patients were admitted, and 67% of them were civilians. Almost two thirds of military personnel admitted were non-surgical cases. The war-related surgical activity was low, corresponding to the low number of war-related injuries. In the period in question 135 emergency operations were performed on military persons. There was considerable out-patient activity at the hospital, covering both military personnel and civilians. Altogether, 12,921 out-patients were treated, 40% of which were civilians. The hospital was well-equipped and well-run. This experience will be helpful in planning future Norwegian task forces abroad.
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Hip replacement surgery is associated with a high frequency of postoperative deep vein thrombosis. This prospective study was performed in order to investigate if routine bedside questioning and examination by the visiting doctor could reveal deep vein thrombosis in the legs of patients who had received a hip replacement. 258 patients were evaluated. Thromboprophylaxis (dextran-70, low molecular weight heparin and graded elastic stockings) was given during the first week after operation. Bilateral venography was performed in all patients on day seven after operation, and showed an overall deep vein thrombosis incidence of 16%. The visiting doctors had not suspected deep vein thrombosis in any of the patients. This may have been because postoperative painful and swollen legs effectively masked any signs and symptoms of deep vein thrombosis. Our results show that deep vein thrombosis during the first week after hip replacement surgery cannot be discovered by clinical diagnostics. The high subclinical frequency of deep vein thrombosis indicates the importance of improving thromboprophylaxis in order to further minimise the occurrence of deep vein thrombosis and the risk of thromboembolic complications.
27 patients (30 elbows) treated with Souter elbow prosthesis replacement were examined at a follow-up study. 26 patients had rheumatic arthritis. The mean observation time was five years (2-10 years). The indication for surgery was severe pain and reduced elbow function. Preoperative radiological examination revealed considerable pathological changes in all the elbows. Six of the elbows underwent revision with new prosthesis replacement. The indications for the re-operations were fractures, loosening of the prosthesis and luxations. 19 elbows (26%) had deteriorated and three patients had no definite opinion. Four of the six elbows replaced by a new prosthesis, became worse than before the first operation. Follow-up radiological examination showed that 80% of the humerus components showed varying degrees of radiological loosening and more than half of the humerus components showed cranial migration. All patients who suffered fractures during the operation have been, or will be, re-operated. Radiological loosening of the prosthesis makes the prognosis uncertain for the majority of the patients. Re-operation with a new prosthesis is unsatisfactory. As a consequence of the poor results, this prosthesis is no longer used at our hospital.
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Discontinuation of thromboprophylaxis a few days after surgery may unmask delayed hypercoagulability and contribute to late formation of deep venous thrombosis (DVT). To investigate whether thromboprophylaxis should be prolonged beyond the hospital stay, a prospective, double-blind randomised study was conducted in 308 patients. All patients received initial thromboprophylaxis with dalteparin, dextran and graded elastic stockings. On day 7, patients were randomised to receive dalteparin (Fragmin) 5000 i.u. once daily, or placebo, for 4 weeks. All patients were subjected to bilateral venography, perfusion ventilation scintigraphy and chest X-ray on days 7 and 35. Patients with venographically verified proximal DVT on day 7 were withdrawn from the randomised study to receive anticoagulant treatment. The overall prevalence of DVT on day 7 was 15.9%. On day 35, the prevalence of DVT was 31.7% in placebo-treated patients compared with 19.3% in dalteparin-treated patients (p = 0.034). The incidence of DVT from day 7 to day 35 was 25.8% in the placebo-treated group versus 11.8% in the dalteparin-treated group (p = 0.017). The incidence of symptomatic pulmonary embolism (PE) from day 7 to day 35 was 2.8% in the placebo-treated group compared with zero in the dalteparin-treated group. This included one patient who died from PE. No patients experienced serious complications related to the injections of dalteparin or placebo. This study shows that prolonged thromboprophylaxis with dalteparin. 5000 IU, once daily for 35 days significantly reduces the frequency of DVT and should be recommended for 5 weeks after hip replacement surgery.
The article describes a case of pseudomyxoma peritonei. The disease is uncommon. The origin is usually a malignant process in the ovary or appendix. The disease spreads to the peritoneal surface, which becomes studded with mucinous bulks. The patient suffered from abdominal discomfort and distension. 80-85% of persons with this disease die within ten years. The disease must be treated with extensive surgery. The case demonstrates the effect of adjuvant chemotherapy. The treatment of pseudomyxoma peritonei must involve co-operation between surgery and oncology.
The article reports a case of pseudolymphoma of the stomach. The histological hallmark is lymphoid hyperplasia, with formation of reactive follicles. Most authors believe that this is a benign disorder. The exuberance of the lymphoid reaction may be misinterpreted, however, as malignant lymphoma, which may possibly explain the unduly good prognosis reported in some earlier studies of malignant lymphoma of the stomach.