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Biomedical subjects

G Antonov

Publications and source records attributed to G Antonov.

7 recordsLinked to original sources
PubMed1980

Experimental studies on the chronic toxic effects of vinyl chloride in rats.

Male rats were exposed to vinyl chloride at the concentrations of 50, 500, and 20 000 ppm, 5 hours daily, 5 days a week for 10 months. Morphological lesions in the liver and the testes detected by light and electron microscope and depression in body weight increase intensified with the duration of exposure. Increased relative weights of some organs and slight hematological and biochemical changes in blood during the course of the experiment were also observed. Some toxic effects including morphological liver injuries arose at the smallest exposure level, i. e., 50 ppm. Assuming 50 ppm as the threshold concentration for rats, the 5 ppm level has been estimated as the safe exposure limit in industry in relation to systemic effects of vinyl chloride.

Alanine Transaminase↗
PubMed1980

Study on the long-term effects of some pesticides.

The hygienic significance of the studies on pesticides from the aspect of their "long-term" effects upon the individual and the generations are emphasized. The basic methods and approaches used in the Laboratory of long-term effects with chemical etiology at the IHOH, Sofia, are discussed, namely for detecting the changes in gonads, reproduction and generation, embryotoxic and teratogenic effects, and changes in cardiovascular system. The results are discussed, namely: fundasol--the effect on gonads, generations, embryotoxic and teratogenic effects, changes in the cardiovascular system; endodan--changes in gonads, reproduction, embryotoxicity; basfungin--embryotoxic and teratogenic effects. All of these studies were performed for the purpose of threshold levels, establishment hygienic standardisation and prognosis of the potential risk for human.

Abnormalities, Drug-Induced↗