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Biomedical subjects

G Aresini

Publications and source records attributed to G Aresini.

8 recordsLinked to original sources
PubMed1976

Occupational type test for the etiological diagnosis of asthma due to toluene di-isocyanate.

An occupational type exposure-test to toluene di-isocyanate (TDI) for the diagnosis of specific respiratory sensitization is proposed. The subjects were tested by exposure to a two-pot polyurethane varnish with and without TDI activator, using a paint-spraying system under standard and controlled conditions, so as not to exceed the threshold limit value of TDI. Forced expiratory volume per second and specific airway resistance (plethysmographic method) were measured before each exposure and during the following 24 h. 47 subjects with clinical symptoms of asthma were examined during their hospital care. For the purpose of this study they were divided into two groups: 42 workers exposed to TDI and 5 not exposed. The preliminary control test, using polyurethane varnish without TDI activator, was always negative and no significant changes in ventilatory parameters were recorded. The spray-painting test, with the same varnish and TDI activator, gave positive responses in 35 out of the 42 exposed workers and negative findings in the group not exposed. This method permits to formulate an accurate diagnosis of TDI respiratory sensitization in the majority of cases (83%). Immediate asthmatic reactions were frequently observed in the exposed subjects with high acetylcholine reactivity. Ten subjects showed a late bronchial reaction (3 h or more after TDI exposure).

Acetylcholine↗
PubMed1975

Functional evaluation of a corticosteroid molecule activity, dexamethasone-isonicotinate, by aerosol dosage in obstructive lung disease.

The authors experimented with a corticosteroid molecule, dexamethasone-isonicotinate, by pressurized aerosol, testing it on 15 subjects suffering from a bronchial obstructive syndrome (7 cases of asthmatic bronchitis, 6 of chronic bronchitis with pulmonary emphysema, 2 of bronchial asthma). In such patients clinical evolution, spirographic patterns, and airway resistance were studied by means of body plethysmograph before and after administration of 0.25 mg dexamethasone-isonicotinate four times a day. In four subjects daily variations of airway resistance before and after 10 days of treatment were evaluated: in three cases the resistance diminished noticeably at all times of the day after therapy. In eleven cases the functional parameters were recorded before and after 7 days therapy, and ten subjects were followed up by a monthly, check during 6 months of therapy. In both methods, the authors obtained good or very good results in more than half of the subjects and fair results in a fifth of the subjects; in the remaining patients poor results were obtained. Side-effects attributed to improper dosage were never observed.

Aerosols↗
PubMed1975

[Lung ductances and the determination of lung diffusion capacity in silicosis].

A study of the behaviour of global and partial lung ductances for CO having for aim to value the lung diffusion function in 97 silicotic workers was undertaken by authors. The workers were divided into three groups according to the Cincinnati classification. The mean values of the global ductance for CO let appear a fall in all the groups when comparison is made with the standard values previously registered in a group of normal subjects. The partial ductances have put in evidence a fall in the mean values below the normal values, only for what concerns the alveolar-capillar ductance for groups 2 and 3. The study of partial ductances in bronchitic and non-bronchitic silicotic subjects lets appear in the first ones a fall in the ventilatory and alveolar-capillar ductances,-- and in the second ones an isolated fall in the alveolar-capillar ductance.

Humans↗