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Biomedical subjects

G Arrigoni

Publications and source records attributed to G Arrigoni.

At least 37 records · Page 2Linked to original sources
PubMed1992

p53 protein expression in central nervous system neoplasms.

AIMS: To demonstrate, immunohistochemically, p53 protein expression in a selection of central nervous system tumours; to investigate the relation between p53 expression and that of the proliferation related antigen, PCNA. METHODS: Surgical specimens from 86 central nervous system tumours were routinely fixed, paraffin wax embedded, and immunostained with a monoclonal (PAb 1801) and a policlonal antibody (CM1) p53 protein and a monoclonal antibody against PCNA (PC10). Normal brain samples obtained at necropsy and 10 surgically obtained samples of gliotic brain parenchyma were also immunostained. RESULTS: p53 protein expression was observed in 35 of 86 brain tumours, suggesting frequent p53 gene mutation. p53 protein alterations were associated with all grades of malignancy in tumours displaying solely astrocytic differentiation, with the exception of pilocytic astrocytomas. In those showing oligodendroglial or ependymal differentiation they appeared to be restricted almost to only high grade lesions. No p53 immunoreactivity was observed in normal or gliotic brain tissue; p53 altered expression was not related to the percentage of PCNA labelled cells. CONCLUSIONS: The use of sophisticated gene amplification techniques or highly sensitive immunohistochemical methods might be useful in distinguishing between reactive and neoplastic astrocytic lesions, and in the identification of malignant progression in other non-astrocytic glial tumours. Tumours with very similar histogenetic differentiation features might actually be a genetically heterogeneous group with possible different clinical courses.

Antibodies, Monoclonal↗
PubMed1992

[Arrhythmogenic Takayasu disease].

The Authors report a case of Takayasu disease in a woman who died at the age of forty-six, in whom the histological examination of the cardio-vascular system revealed giant cells granulomatous arteritis localized in the aortic arch and collateral arteries; endocarditis and granulomatous coronaritis. The bases of arrhythmogenic alterations, in this study, take into account the thrombosis of the conduction system arteriolar vessels and the phlogosis extending to the cardiac plexus.

Adult↗
PubMed1990

Familial spastic paraplegia with peroneal amyotrophy. A family with hypersensitivity to pyrexia.

We describe 4 siblings with spastic paraparesis and peroneal amyotrophy who were prone to severe pain and painful dysesthesias, tetraparesis and pyramidal signs during pyrexial episodes of variable etiology. These symptoms cleared almost completely in 10-20 days. Nerve conduction velocity was reduced more markedly during the spells of fever. Muscle biopsy specimen was normal. Some transient functional disturbance of membrane equilibrium of the nervous pathways of both central and peripheral nervous systems was probably responsible for the attacks during pyrexial episodes.

Adolescent↗
PubMed1990

Persistent memory impairment after high altitude climbing.

High altitude climbing without supplementary oxygen is a common sporting practice and athletes have been extensively evaluated with respect to possible brain functional impairment during its performance. Little is known on the contrary about long-term effects of hypoxia on the central nervous system. We evaluated, at sea level, a group of 10 high-altitude climbers with a battery of neuropsychological tests before and 75 days after the ascent. Our results suggest the occurrence of an impairment of memory performance after return to sea-level at least in some subjects, while speech and certain practical abilities were unchanged.

Adolescent↗
PubMed1989

[Hartmann's operation in complicated lesions of the sigmoid and rectum].

A personal series of 49 Hartmann's operations carried out in the period 1975-1986 for complicated rectal-sigmoid lesions, 43 for cancer and 6 for diverticular sigmoiditis, are reported. Fully 45 of these patients (92%) were operated on in emergency conditions and the choice of the operation was imposed by the gravity of the lesions observed. In the light of this series and a review of the literature, it is maintained that the operation still has a place in complicated rectal-sigmoid lesions, especially under emergency conditions and in patients at risk for age and general conditions, it being very well tolerated and consenting recanalisation if necessary.

Aged↗
PubMed1987

[Intravenous leiomyomatosis with uterine onset and extending to the heart. Value of the radiological study].

Two cases are reported of intravenous leiomyomatosis with extension of neoplastic thrombus to the right atrium; an histological documentation of each patient has been successfully obtained during surgical procedure. International literature is reviewed and a useful diagnostic protocol for the correct evaluation of these patients is suggested, in order to choose the best surgical approach. The important role of CT with intravenous injection of contrast medium is pointed out. The advantages resulting from the use of echotomography and from angiographic study of the inferior vena cava are stressed.

Adult↗
PubMed1979

Reimplantation of the mandibular condyle in cases of intraoral resection and reconstruction of the mandible.

A new technique for the reconstruction of the disarticulated ramus is presented. From an intra-oral approach the mandible is resected, and if the posterior part of the ramus and the neck of the condyle are not involved by the tumour, this part is preserved. It is then fixed to the bone graft from the iliac crest bridging the remaining defect. The procedure is outlined, based on the experience of 4 cases which have been successfully operated on according to this technique. The earliest of them has been followed-up for seven years.

Adult↗