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Biomedical subjects

G Asch

Publications and source records attributed to G Asch.

At least 19 recordsLinked to original sources
PubMed1989

[Ossification after transplantation of model cartilage in the rat patella].

The cartilage model of the rat's patella constitutes a formation susceptible of inducing ossification, following its transplantation in a variety of sites (muscle, thyroïd, testis, ovary, anterior chamber of the eye, etc.), including those considered inappropriate in other experiments of induced ossification (liver, kidney). So we have an experimental model allowing the influence on the osteogenesis of various factors, local or general, natural or experimental, to be studied. Ossification occurs in this model only in cases of histocompatibility between donor and recipient. It is constant after autotransplantation or isotransplantation. It is never seen after heterotransplantation. In cases of homotransplantation its frequency varies: this is not influenced by the technical conditions of implantation but by tissue compatibility and the age of the animals giving and receiving. A private perichondrium cartilage retains its osteogenic potency. A cartilage killed by alcohol or cold no longer demonstrates its osteoformative capacities, even when put into contact with a living cartilage. Our findings are difficult to reconcile with the hypotheses invoking the osteogenic potency of the periosteum, or the intervention of substances either inducing osteoformation or inhibiting vascular invasion, for the explanation of endochondral ossification. However, they lead one to the opinion that chondrocytes play an active role in its release.

Aging↗
PubMed1988

[Experimental studies on the factors of osteogenesis by transplantation of patellar cartilage framework in rats].

The cartilage framework of the patella in rats is capable of inducing ossification after homotransplantation in many various sites: muscle, thyroid, testicle, ovary, kidney, anterior chamber of the eye, etc. The frequency of ossification does not depend on the technical conditions of the transplant, but on the age of the donors and receivers; it approximates 84 p. cent when the two rats are three weeks old. It is close to 100 p. cent in case of autotransplant. It is non-existent in case of heterotransplantation. A cartilage that is killed by alcohol or cold, has no longer osteogenetic abilities, even if it is placed in contact with live cartilage. The transplant of patellar cartilaginous framework represents a model which may be used to study the factors responsible for physiological ossification as well as the effect of various experimental conditions on osteogenesis.

Animals↗
PubMed1982

[Urinary calcium and phosphate during fasting. Effect of various hormonal factors (author's transl)].

Obese patients who fasted during seven days were divided into four groups according to whether they received triiodothyronine (100 to 150 microgram per day), calcitonin (1 MRC unit per day), both T3 and calcitonin, or neither of these two hormones. Urinary calcium and phosphate were increased in patients receiving T3 or calcitonin. T3 given with calcitonin did not increase the calcitonin-induced calciuria but did increase the phosphaturia. The authors suggest a possible explanation for these findings. No changes in serum parathormone were recorded during fasting acidosis.

Adolescent↗
PubMed1980

[Mechanism of fasting hyperuricemia].

The authors followed up 73 obese patients submitted to fasting for 7 days; 46 of them took nos drugs (control subjects); the others took daily 100 to 200 mg of benzbromarone. The average serum uric acid of the controls rose from 49.37 mg to 90.52 mg per litre. Their uric acid clearance during the week of fasting fell to 4.67 ml per minute. The uric acid turnover was multiplied by two and the mixable pool by 3.5. These results that the hyperuricemia of fasting is due both to a fall in uric acid clearance and increased catabolism of cellular nucleic acid.

Adolescent↗