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G Atassi

Publications and source records attributed to G Atassi.

At least 73 records · Page 4Linked to original sources
PubMed1982

N-methylformamide: antitumour activity and metabolism in mice.

The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In all cases N-methyl-formamide had significant activity, formamide had marginal or no activity and N-ethylformamide had no significant activity. N-methylformamide and N-ethylformamide were equitoxic to the TLX5 lymphoma in vitro. Formamide was found as a metabolite in the plasma and urine of animals given N-methylformamide and N-ethylformamide, but excretion profiles do not support the hypothesis that formamide is an active antitumour species formed from N-alkylformamides. No appreciable metabolism of N-methylformamide occurred under a variety of conditions with liver preparations in vitro. N-methylformamide, but not N-ethylformamide or formamide, reduced liver soluble non-protein thiols by 59.8% 1 h after administration of an effective antitumour dose.

Animals↗
PubMed1982

Investigation of the in vivo anti-invasive and anti-metastatic effect of desacetyl vinblastine amide sulphate or vindesine.

In a study of the effect of vindesine (VDS) against metastases of murine tumours in vivo, we demonstrated that VDS produced an anti-metastatic effect on tumours with invasive properties, such as Lewis lung carcinoma or Madison 109 lung carcinoma, while no effect was observed against lymph node metastases of the subcutaneously implanted P388 tumour model. Local systemic mechanisms favouring or opposing the phenomena of invasion, dissemination, and establishment of secondary malignancies may explain the differences between the various models. Although our data did not allow us to conclude that VDS has specific anti-invasive properties in vivo, its inhibitory effect against secondary tumour growth agrees with the assumption that invasion is an important step in the establishment of metastases.

Animals↗
PubMed1978

Influence of micrococcus, BCG and related polysaccharides on the proliferation of the L1210 leukaemia.

A comparative study of the effects of BCG, Micrococcus lysodeikticus, and a series of structurally related polysaccharides (complement triggers) on the non-specific and specific immune resistance against L1210 lymphoid leukaemia was carried out and commented on. In contrast with authors of earlier reports, we were unable to generate any effective non-specific or specific immunotherapy after the graft of 10(4) leukaemic cells to 8--10-week-old CDF1 mice. However, when mice were prevaccinated with irradiated (8 krad X-rays) cultured cells combined with 1 mg of bacterium or polysaccharide one month before grafting 10(4) cells, they were given an immunoprotection that was more pronounced with the i.p. than with the i.v. route. Prevaccinated mice were afforded a stronger immunoprotection when boosted repeatedly with 1mg injections of bacterium or polysaccharide after tumour challenge.

Animals↗