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Biomedical subjects

G B Collins

Publications and source records attributed to G B Collins.

34 records · Page 2Linked to original sources
PubMed1982

Identification of aneuploids in Nicotiana tabacum by isozyme banding patterns.

A biochemical system was devised to identify aneuploids of Nicotiana tabacum. Leaf tissue from 6 nullihaploids, 4 nullisomics, and 10 monosomics was analyzed electrophoretically on slab acrylamide gels. The staining systems used were for peroxidase, esterase, superoxide dismutase, malate dehydrogenase, and glutamate oxaloacetate transaminase. Nullihaploids and nullisomics could be distinguished from each other and from haploid or disomic types by their unique isozyme banding patterns. The banding patterns of the monosomics closely resembled those of the disomic. Morphologically similar aneuploids from different populations had similar isozyme banding patterns.

Aneuploidy↗
PubMed1982

Organochlorine pesticide residues in human milk in Great Britain, 1979-80.

1 The concentrations of some organochlorine pesticides and polychlorobiphenyl compounds have been determined in 102 samples of human milk collected between January 1979 and September 1980. 2 Comparison of the results with those from a limited study undertaken in 1963-4 shows a decline in residues' levels. 3 The concentrations of organochlorine pesticides and polychlorobiphenyls in human milk samples from residents in Great Britain compare favourably with data obtained in other countries.

Female↗
PubMed1981

Organochlorine pesticide residues in human fat in the United Kingdom 1976-7.

Between May 1976 and August 1977 samples of human body fat were taken during routine necropsies in the United Kingdom on 236 subjects aged over 5 years and four infants aged under 4 months. Comparison with results from earlier studies showed a further decline in residues of pp'-dichlorodiphenyltrichloroethane (pp'-DDT) and dieldrin (HEOD) and increased amounts of hexachlorobenzene residues; concentrations of other compounds were similar to those observed in the studies carried out in 1963-4, 1965-7, and 1969-71. Comparison of the data with those from other countries, showed that the concentrations of organochlorine pesticide residues and polychlorobiphenyls in human fat samples from residents of the United Kingdom remain among the lowest in Europe and, indeed, the world.

Adipose Tissue↗
PubMed1981

Treatment of alcoholism: the role of the primary care physician.

The primary care physician plays an important role in early identification of the alcoholic, who may seek treatment for a problem other than alcoholism. Confrontation begins with a complete history and ends with an invitation to the patient to participate in definitive treatment. During detoxification the patient can be helped to establish a long-term relationship with the physician and with Alcoholics Anonymous.

Alcoholism↗
PubMed1981

Propoxyphene dependence: an update.

Despite the initial claims that propoxyphene (Darvon) provides analgesia without risk of dependence, there is growing international recognition of its addictive potential, with documentation of both psychological dependence and physical withdrawal symptoms. However, many physicians remain uninformed of the true nature of the drug and its potential for abuse and addiction. In terms of frequency of addiction among users, propoxyphene may be less dangerous than most narcotics, but it is more available by prescription and less expensive then illegal opiates, making it a prime target for both abuse and addiction. At present, increased caution by prescribing physicians is indicated. Patients now taking the drug should be carefully monitored for signs of abuse or dependence.

Adult↗
PubMed1980

A hospital day care program for alcoholics.

A high drop-out rate for conventional outpatient counseling of alcoholics led to implementation of a hospital-based intensive day care program in which patients attend treatment activities at the hospital throughout the day for ten days. During the day care program, patients are introduced to aftercare with supportive counseling and Alcoholics Anonymous. Day care has been found to enhance program flexibility to meet specialized patient needs, and to dramatically reduce the number of drop-outs. Significant short term improvement is noted in 41.6% of patients treated with intensive day care. Intensive hospital-based day care is proving to be a low cost, effective treatment modality. Long term outcome studies are suggested.

Alcoholism↗
PubMed1979

Using the resources of AA in treating alcoholics in a general hospital.

At Cleveland Metropolitan General Hospital a small number of staff and a large number of volunteers from Alcoholics Anonymous have collaborated to meet the treatment needs of the community's alcoholics. Recovered alcoholics serve as volunteers staffing a friendship room, located close to the emergency room and open weeknights between 6 and 10 p.m. They also provide counseling on AA, escort patients to AA meetings, help in postdischarge follow-up, and act as casefinders in the community. The hospital staff have become more aware of problems of alcoholism and are better able to treat alcoholics and to provide counseling and referral services.

Alcoholics Anonymous↗
PubMed1972

Organochlorine pesticide residues in human fat in the United Kingdom 1969-71.

During the period 1969-71 samples of human body fat were taken during routine necropsies on 201 subjects over 5 years old and 20 stillborn babies and infants under 5 years old, and analysis was carried out for organochlorine pesticide residues. By comparing the results from this period with those from similar studies undertaken in 1963-4 and 1965-7, it is clear that a downward trend continues.

Adipose Tissue↗
PubMedDate not supplied

Symptom-modulating properties of peanut stunt virus satellite RNA sequence variants.

The symptom-modulating properties of three peanut stunt virus (PSV) satellite RNA (satRNA) sequence variants were studied. The (V)-satRNA did not affect symptom development in tobacco plants infected with PSV. The (G)- or (WC)-satRNA, on the other hand, attenuated the symptoms. In these plants, the symptoms of PSV were restricted primarily to the inoculated leaves, and in some cases, a few leaves above the inoculated leaf showed small chlorotic areas. Northern blot analysis of total nucleic acids from PSV-infected plants containing the (V)-satRNA revealed the presence of both satellite and viral RNAs in inoculated leaves as well as in systemically infected leaves. On the other hand, satellite and viral RNAs were detected in the inoculated but not in the noninoculated leaves from infected plants containing either (G)- or (WC)-satRNA. Although a decrease in the quantities of genomic RNAs 1, 2, and 3 was characteristic of all satRNA-containing plants, this effect was more evident in the case of (G)- and (WC)-satRNAs. The complete nucleotide sequences of the three satRNAs were determined and compared to the published sequence of PSV satRNA. The (V)-satRNA differed from the published sequence at two positions, whereas the (G)- and (WC)-satRNAs differed at six and eight positions, respectively. Comparison of the nucleotide sequence of the satRNA having no effect on PSV-induced symptoms with those reducing virus symptoms suggests that a single nucleotide change or as many as five nucleotide changes may distinguish between attenuating and nonattenuating satRNAs.

Arachis↗