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Biomedical subjects

G B ELLIOTT

Publications and source records attributed to G B ELLIOTT.

At least 19 recordsLinked to original sources
PubMed1965

GLOMUS-LIKE BODIES ON THE SUPERIOR MESENTERIC ARTERY.

Minute endocrine-like structures have been detected where the cranial parasympathetic nerves cross a main vessel which carries blood to the heart, brain or arms. This suggests that their sites are fixed by function. These structures are the vago-tympanic and jugular glomera in the depths of the petrous bone near the jugular vein, carotid bodies, and aortic arch bodies, at crossings by the vagi. They have not been found in the human abdomen, although primary tumours with their endocrine-like structure do occur there.With the thought that these non-chromaffin glomus bodies may be the multiple miniature parasympathetic homologues of the adrenal medullae, a microscopic search was made for them at the root of the superior mesenteric artery. In 10 out of 15 aortas, glomera similar in appearance to the carotid body were found near the midline, about 1 cm. distal to the root of the artery and some 3 mm. external to its adventitia. In a single median section of celiac artery, one of these bodies was also found in a corresponding position. These form vital links for the concept that such bodies are parasympathetic endocrines. Because these bodies were discovered in two of the possible locations predictable for them in the human abdomen, the view that they comprise a definite system is strongly supported.

Aortic Bodies↗
PubMed1965

AN IMMUNO-ELECTROPHORETIC APPARATUS: STUDIES IN TUBERCULOSIS.

Serum applied as a streak to a strip of filter-paper can be separated into six main bands, depending upon respective molecular weights (electrophoresis). When such bands of protein are exposed to a polyvalent anti-human serum diffusing in at right angles, at least 18 protein components can be identified as precipitation arcs (immunoelectrophoresis).Using immunoelectrophoresis, 202 sera taken at intervals from 86 patients with tuberculosis were compared with 160 sera from healthy persons and patients with non-tuberculous disease. With clinical recovery from tuberculosis, shrinkage of the beta-2 macroglobulin band was observed, and a gamma-1 globulin arc appeared or was accentuated. This finding suggests an early antibody response of large molecules, and a later defence by slowly developing small molecules, as seen in many common infections. The macroglobulins involved were found to be selectively adsorbed on attapulgite clay particles. This technique should be useful in developing serological tests for active tuberculosis.The apparatus used was designed and built by the authors at trivial cost. Its construction and operation are described.

Equipment and Supplies↗
PubMed1963

PASTEURELLA SEPTICA INFECTIONS IN HUMANS.

Five instances of infection by Pasteurella septica, an organism which closely resembles H. influenzae on methods of presumptive bacteriology, are reported from an acute treatment general hospital practice over a period of three months. This infection decidedly outnumbers those caused by other Pasteurella species in North America. The organism is apt to be identified as H. influenzae, Friedlander's bacillus or Mima polymorpha. Unlike these, it shows extreme sensitivity to penicillin, sometimes combined with resistance to antibiotics that inhibit or kill these other organisms.While in the past Pasteurella septica infection was considered to be characterized by persistent local infection following domestic animal scratches or bites, it is clear that it is more often found in cases of respiratory tract infection and peripheral septic disease. In three of the five cases reported, exposure to animals was the source of infection.Because mixed infection with confusingly similar organisms may occur, lack of awareness of extreme penicillin sensitivity of Pasteurella septica may account for persistent failure of antibiotic therapy.

Animals↗
PubMed1963

Serum protein electrophoresis in tuberculosis.

Serial serum protein electrophoretic determinations at two-month intervals were carried out on 84 tuberculous patients undergoing treatment in a sanatorium. An attempt was made to correlate changes in the albumin/alpha-2 globulin ratios and gamma globulin levels with clinical and roentgenographic status. It was observed that before treatment of the tuberculous process the albumin/alpha-2 globulin ratios were low and the gamma globulin levels were increased. As improvement occurred, albumin/alpha-2 globulin ratios increased and gamma globulin values decreased. A poor prognosis was indicated by decreasing albumin/alpha-2 globulin ratios. Electrophoretograms are of particular value in assessing the effect of surgery, especially when roentgenographic studies are not informative. They are also a valuable guide in deciding upon the duration of therapy necessary for individual cases.

Blood Protein Electrophoresis↗