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Biomedical subjects

G B Fedoseev

Publications and source records attributed to G B Fedoseev.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Mechanisms of asthma of effort].

Forty-six patients with bronchial asthma and preasthma and 6 normal persons were examined before and after graded exercise. Measurements were made of changes in glycogenolysis in peripheral lymphocytes, in blood plasma osmolarity, external respiration function ad diffusion capacity of the lungs, and of blood and sputum eosinophilia. Some of the patients were also examined for blood content of catecholamines. The group of patients with asthma of effort showed, in contrast to those without that illness, the signs of allergic inflammation of the distal parts of the bronchi and a direct correlation between changes in plasma osmolarity and glycogen content in lymphocytes, a decrease in the grade of the glycogenolytic response to adrenaline after exercise. It seems likely that in the pathogenesis of asthma of effort, of certain importance is inadequate reaction of the adrenoreceptor apparatus of the cells to the changes in the microenvironment provoked by exercise, which is manifested by the lack of the rise of beta-adrenoreactivity.

Asthma↗
PubMed1987

[Chronoprevention and chronotherapy of bronchial asthma].

Chronobiological investigation of external respiratory function parameters was conducted in 93 patients with preasthma and bronchial asthma and in 13 healthy persons. The peculiarities of circadian organization of external respiratory parameters which were used for administration of chronotherapy were revealed in the patients. Some time before the appearance of maximum deterioration of indices under study, mostly indices of bronchial permeability, drugs (broncholytics, inhalation steroids and intal) were administered. Objective and subjective methods of assessment of bronchial permeability using a diary of self-evaluation were compared. The substitution of laboratory investigation for self-evaluation will make it possible to widely use chrono-diagnosis and chronotherapy for patients with bronchial asthma, and chronotherapy was found to be more effective than commonly used therapeutic schemes.

Adolescent↗
PubMed1986

[Rhinobronchial reflex in patients with bronchial asthma].

Altogether 229 patients with bronchial asthma and 57 patients with chronic bronchitis (preasthma) were examined. Diseases of the respiratory tracts, mainly of the nasal cavity and accessory nasal sinuses were found in 273 (95.45%) patients. There was correlation of the cell structure of the upper and lower respiratory tracts in patients with bronchial asthma as well as correlation in the status of the nasal and bronchial cavity mucosa. A raised rhinobronchial reflex was revealed in 33.7% of patients with bronchial asthma and a raised olfactobronchial reflex in 46.2%. Latent hyperreactivity of the bronchi was detected in 21.7% of the patients with vasomotor rhinopathy without concomitant pulmonary pathology.

Adolescent↗
PubMed1985

[Circadian organization of the indices of external respiration in bronchial asthma patients].

Circadian rhythms of external respiration function (ERF) and body function (BF) were studied in 20 patients with mild bronchial asthma, 20 patients with bronchial asthma of medium gravity and in 14 healthy subjects. Circadian rhythms of the medium-group parameters of ERF were shown to be statistically insignificant, whereas individual circadian chronograms demonstrated circadian rhythms for all the patients with BA and healthy subjects. Essential differences were found in the organization of the temporary structure of circadian rhythms of ERF in BA patients and healthy subjects. It was discovered that in BA patients, the maximal pathological alterations develop within the period from the midnight to 8 a. m., whereas the minimal disorders of ERF are recorded within the period from the noon to 8 p. m. It is suggested that deterioration of bronchial patency which brings about the development of obstruction in BA patients is the result of hypersynchronization and increased amplitude of the circadian rhythms of those parameters of ERF which determine the bronchial patency.

Adult↗