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Biomedical subjects

G B Irsigler

Publications and source records attributed to G B Irsigler.

9 recordsLinked to original sources
PubMed1979

Progesterone in obese patients with respiratory failure.

Two obese patients with acute respiratory failure are described. Both required mechanical ventilation to reverse the respiratory acidosis. On recovery, the major abnormality was failure of ventilatory response to inhaled carbon dioxide. After oral progesterone (100 mg/day and 20 mg/day, respectively) the slope of the carbon dioxide response line increased from 0,02 to 1,14 I min-1 mmHg-1 and from 0,04 to 1,14 I min-1 mmHg-1, respectively. This was associated with sustained clinical remission in 1 patient.

Carbon Dioxide↗
PubMed1978

Comparison of carbuterol and hexoprenaline aerosol in bronchial asthma.

A new beta 2-adrenergic bronchodilator, carbuterol, was compared with hexoprenaline and placebo, by double-blind crossover technique in 10 adult asthmatic patients. Carbuterol 200 microgram was compared with hexoprenaline 200 microgram, corresponding to 2 inhalations from a standard aerosol in each case. The carbuterol effect, in terms of vital capacity and forced expiratory volume in 1 second (FEV1) was significantly longer than that of hexoprenaline. Its effect on airways resistance also appeared to be longer, although this difference was not statistically significant. The difference in duration of action may be due to greater potency of carbuterol, or to a longer elimination half-life of carbuterol. No significant effects on heart rate or blood pressure were noted with either drug.

Adolescent↗
PubMed1976

The diagnostic value of the tine and Mantoux tests in a general hospital.

Tine and Mantoux tuberculin tests were compared in 193 hospitalised White patients with a variety of illnesses. With the Mantoux test 52 (27%) were tuberculin-positive and 19 (9.8%) were positive with the tine test. Had the tine technique alone been used, 33 of 52 tuberculin reactors would have been missed. Additional findings were (i) a 73% positivity for Monilia antigen; (ii) the optimal time for reading the Mantoux tests was on the third, rather than the second day; (iii) tuberculin reactivity was not suppressed by either pyrexia or elevation of the sedimentation rate; and (iv) the use of avian PPD demonstrated very few reactors in this population. It is recommended that the tine test be replaced by the intradermal Mantoux test with stabilised freeze-dried PPD tuberculin supplied in test kits with diluent. This matter should be given high priorty in South African general hospital practice and population surveys.

Adolescent↗
PubMed1976

Carbon dioxide response lines in young adults: the limits of the normal response.

Carbon dioxide responsiveness was determined in 126 normal, young adults. The mean +/- SE slope of the line relating PCO2 to minute volume of ventilation was 2.60 +/- 0.107 liter per min-mm Hg. Although a wide range of responses was noted, 80 percent of the subjects had a value for the slope between 1.5 and 5.0 liter per min - mm Hg, with 16.6 per cent having values lying below and 4 per cent above this range. Women were significantly less responsive than men. Low, but significant, correlations were found between the slope and vital capacity, and between the slope and maximal breathing capacity, but not between the slope and height, weight, age, or smoking habits. Additional findings included an increase in the slope with prolonged rebreathing, possibly due to a peripheral chemoreceptor effect; absence of metabolic acidosis during 4 min of rebreathing; excellent short-term reproducibility of results in 111 subjects; and good longer-term reproducibility in most of 10 subjects retested 9 to 24 months later.

Adult↗