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Biomedical subjects

G B Koval'skiĭ

Publications and source records attributed to G B Koval'skiĭ.

At least 19 recordsLinked to original sources
PubMed2005

[Androgen and estrogen receptors in intact, hyperplastic, peritumorous and malignant prostate tissues: a link to proliferation and apoptosis (immunochemical study)].

A total of 134 samples of intact prostate tissue, nodular hyperplasia and prostate cancer were examined. Number of androgen-positive cells was 28.51 +/- 3.50%, Ki-67 expression index - 2.76 +/- 0,45% and Bcl-2--6.25 +/- 1.38% in nodular hyperplastic tissue. In peritumorous epithelial tissue, that parameter dropped to 20.60 +/- 3, 10%, while stromal E+ cells index rose to 19.42 +/- 4, 81. Androgen expression varied 40-90% in tumor epithelium and that of Ki-67--8.26-13.93. Bcl-2 expression was lower in recurrent tumor (4.95 +/- 2.76) as compared with adenocarcinoma microfoci (5.41 +/- 0.71).

Aged↗
PubMed2002

[On the etiology of aortal insufficiency].

The authors describe the results of valvulometry, traditional histological and cytological investigations of dissected valves of 1084 patients and an analysis of causes of aortal insufficiency as compared to the literature data for the last 80 years. The main causes of heart valve diseases are considered to be mesenchymal dysplasia and infective endocarditis.

Adult↗
PubMed1984

[Age-related characteristics of structural support for ovarian function].

Histoenzymological assay was used to investigate various structures of the ovaries of rats of two groups aged 3-4 and 12-14 months during estral cycle. The activity of 3 beta-, 17 beta- and 20 alpha-steroid dehydrogenases, glucose-6-phosphate dehydrogenase, NAD and NADP-diaphorases, esterase, acid and alkaline phosphatases was studied. It has been shown that transport alterations in the microcirculation including the hematofollicular barrier play, the leading part in age-dependent depression of reproductive and endocrine functions. Ageing rats demonstrated no linkage between endothelial, thecal and granular cells, which points to the injury of the histophysiological mechanisms of the follicular system integration.

Aging↗
PubMedDate not supplied

[Etiological diagnosis of isolated stenosis of the aortic valve].

We tried to objectivize etiologic diagnosis of isolated aortic stenosis. We studied 950 valves removed during operation on the heart and 15 valves of the dead patients without cardiac pathology using automatic semi-quantitative microscopic description of the valve pathology with further calculation of informative value of the signs. As a result of our investigation the list of the most important signs for the differential diagnosis was compiled. We found out that most often causes of aortic stenosis are calcinosis of bicuspid aortic valve and senile calcinosis. Silvering of the nucleolus organiser in endotheliocytes and fibroblasts in various pathology of the aortic valve showed an increase in the metabolism level and plastic possibilities of the cells in aortic calcinosis.

Aortic Valve↗
PubMedDate not supplied

[Proliferation and apoptosis of epithelium in prostate cancer, in a peritumor region, and in benign hyperplasia].

Indices of Ki67, Bc12 expression, mutant gene p53, nucleolar organizers activity and the percentage of cells having nucleic acids levels higher or lower of the diploid levels were determined in prostatic epithelium in cancer, in the peritumorous area and in the area of benign prostatic hyperplasia. A considerable variability of the tumor epithelium by the level of proliferative activity, apoptosis inhibition and expression of mutant p53 gene was established. Increased proliferative activity and predominance of epitheliocytes with a nucleic acids level higher as compared to the diploid one were revealed in the tumor epithelium. Low apoptosis inhibition and increased degradation of the epithelium in case of a high level of Ki-67 expression index were noted in the peritumorous area. Changes in the peritumorous region were noticed both very close to the tumor lesion as well as at considerable distance from it.

Apoptosis↗
PubMedDate not supplied

[Comparison of the indices of occurrence of the diagnoses as a method of assessing the quality of histological diagnostics (using intraepithelial and invasive uterine tumors as an example)].

The method of comparison of frequency of intraepithelial and invasive tumours established on biopsy and surgical material of uterine cervix and body is proposed. The frequency of invasive and intraepithelial tumours of uterine cervix in different anatomo-pathological cervices of general profile was 0.8-5.3% and 1.5-42.7% respectively, those of uterine body 0.2-2.2% and 0-2.3%. Frequency of uterine body tumour diagnoses was significantly higher at the age over 40 years. As a control of frequency it is suggested to consider maximum diagnoses at minimum level of errors: 8.4 +/- 2.2% diagnoses of intraepithelial and invasive tumours of the uterine cervix and 1.5 +/- 0.7% (2.1 +/- 1.1% in patients over 40 years)--of uterine body.

Carcinoma in Situ↗
PubMedDate not supplied

[Structure and organization of the activities of the pathology services for adults in St. Petersburg].

Principles of organization of St. Petersburg pathology service are outlined. The service covers the Consultative and Methodological Council, the Department of Management and 53 departments including 12 departments attached to the city pathology bureau. The main problems of the service concern inadequate financing and material-technical support, lack of specialists in conditions of increasing amount of work (25,870 autopsies, about a million of intraoperative biopsy examinations, 72,000 cytological examinations performed in 2001).

Adult↗
PubMedDate not supplied

[Isolated stenosis of the aortic orifice].

Five known to-day causes of the isolated aortal valve stenosis are reviewed: 1) atherosclerosis, 2) premature calcinosis of congenital bicuspidalis aortal valve; 3) rheumatism; 4) infectious endocarditis; 5) mesenchymal dysplasia. The authors consider that aortal valve calcinosis developing against the background of valve atherosclerosis complicates the above diseases and differential diagnosis of aortal stenosis causes.

Aortic Valve Stenosis↗
PubMedDate not supplied

[Mesenchymal dysplasia of heart valves, cystic medianecrosis of the aorta and herpetic infection].

Histologic and immunohistochemical studies (use of antibodies for viruses of herpes simplex type 1 and 2, desmin, vimentin, SMA as well as polymerase chain reaction to DNA of viruses of herpes simplex) were made on the material of the valves taken from 1326 patients with valvular heart disease, the ascending aorta of 30 patients with aneurysm, valves of 35 deceased patients without cardiovascular pathology. As a result, expression of viruses of herpes simplex type 1 and/or 2 was found in all cases with mesenchymal dysplasia and cystic medianecrosis in endotheliocytes, fibroblasts, smooth muscle cells of valves and aorta. This indicates the role of these viruses in the pathogenesis of these diseases and their common etiology.

Actins↗
PubMedDate not supplied

[Proliferative activity by expression of antigen Ki-67 in solitary and multiple synchronous epithelial tumors of the colon].

Proliferative activity of sigmoid and rectal mucosa, and that of single and multiple (synchronous) adenomas and adenocarcinomas of the colon has been studied. A significant difference between antigen Ki-67 expression index in normal mucosa, adenomas and adenocarcinomas, and also in single and multiple colorectal cancers has been revealed.

Adenocarcinoma↗