G B Schemmer | PubMed Health

PubMed1987

Posttraumatic Bacillus cereus endophthalmitis.

We encountered a patient who developed Bacillus cereus endophthalmitis following trauma. Early therapy, which included intravitreal clindamycin phosphate and gentamicin sulfate, resulted in a visual acuity of 20/60. A five-year retrospective review of all cases of endophthalmitis following trauma reported at our institution revealed Bacillus as the infecting organism in six (46%) of 13 culture-positive cases. The high frequency of virulent Bacillus infections in the setting of trauma necessitates the use of antibiotics that are active against this organism in posttraumatic endophthalmitis. The combination of clindamycin and gentamicin can be effective therapy in Bacillus species infections if used early in the course of the disease.

Accidents, Occupational↗

PubMed1983

Effect of topical antibiotic solutions on corneal epithelial wound healing.

The eight topical antibiotic solutions that we use most frequently were tested for their effect on corneal epithelial wound healing in the rabbit. Five percent cefazolin sodium and a mixture of neomycin sulfate, polymyxin B sulfate, and gramicidin (Neosporin) had the least effect on epithelial healing rates and quality of healing, 10% sulfacetamide sodium and an artificial tear had intermediate effects, and gentamicin sulfate, tobramycin, and chloramphenicol were the most toxic. No substantial differences were found between gentamicin and the newer aminoglycoside, tobramycin, and the "fortified" preparations of these two drugs did not seem to be more toxic than the 0.3% solutions. Therefore, topical antibiotic solutions vary in their effects on the corneal epithelium, and not all antibiotics should be considered innocuous when used in the treatment of epithelial defects.

Administration, Topical↗