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Biomedical subjects

G B WEST

Publications and source records attributed to G B WEST.

At least 19 recordsLinked to original sources
PubMed1961

Some effects of corticosteroids on the metabolism of histamine and 5-hydroxytryptamine in the rat.

Daily intramuscular injections of cortisone, prednisolone, triamcinolone, fludrocortisone and 2-methylfludrocortisone reduced the histidine decarboxylase activity of the rat liver, but increased the enzyme activity of the pyloric stomach. Injections of histamine liberators or exposure to cold produced similar changes. After adrenalectomy, the histidine decarboxylase activities of the liver and pyloric stomach were unaltered, but the histaminase activity of the ileum was reduced. The 5-hydroxytryptophan decarboxylase activities of rat liver and kidney were not altered by treatment with corticosteroids.

Adrenal Cortex Hormones↗
PubMed1960

The effects of corticosteroids and related compounds on the histamine and 5-hydroxy-tryptamine content of rat tissues.

Daily intramuscular injections of cortisone, prednisolone, triamcinolone, dexamethasone, fludrocortisone and 2-methylfludrocortisone markedly reduced the histamine and 5-hydroxytryptamine contents of the skin and small intestine of rats; there was an increase however, in the amine contents of the stomach. The sex hormones were weaker in these effects while deoxycortone and corticotrophin were inactive. When the skin was depleted of half of its 5-hydroxytryptamine by prolonged treatment with polymyxin B, the rate of recovery of this amine was retarded by the glucocorticoids. The glucocorticoid activity of a steroid and its ability to produce changes in the histamine and 5-hydroxytryptamine contents of tissues are related.

Adrenal Cortex Hormones↗