[Ovulation induction in Kallman syndrome by intravenous pulsatory infusion of gonadotropin releasing hormone].
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to G Bártfai.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The contraceptive efficacy and side effects of postcoital levonorgestrel used repeatedly during the peri-ovulatory period of one cycle was examined in 259 women. All subjects were of proven fertility in their present union and had ovulatory cycles as assessed from pre-treatment BBT charts. The mean number of coital acts during the treatment cycle was 7.5 (SD:2.6) and the mean number of 0.75 mg levonorgestrel tablets taken during the peri-ovulatory period was 4.0 (SD:1.2). Two pregnancies, both considered to be method failures, occurred, giving a failure rate of 0.8% per treated cycle. Although the overall effect of levonorgestrel on menstrual cycle length was small and insignificant, menstrual cycle disturbances were not uncommon. Intermenstrual bleeding or spotting occurred in 8.5% of the treated cycles and 12.5% of the cycles were less than 20 or more than 35 days. Other side effects, mainly nausea, headache and dizziness, were reported by about 20% of the subjects but the apparent incidence of these complaints varied markedly between the nine participating centres from 0% to just over 50%. The data suggest that repeated postcoital use of levonorgestrel is probably not a viable approach to fertility regulation for the majority of women who have regular intercourse and wish to limit the number of their pregnancies.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Fetal breathing movements and nonstress test were examined in 104 non-selected pregnant women between weeks 38-42 of gestation. A significant relationship existed between either the presence or absence of fetal breathing movements and results of the nonstress test as judged by the one-, and five minute Apgar score or the incidence of fetal distress in labour. Significantly more information can be gained about the status of the fetus by combination of the methods than by employing any of the two alone.
Cardiotocograms were prepared in 127 cases on 120 pregnant women, first by abdominal electrocardiography, and immediately afterwards by ultrasound cardiography. A study was made to ascertain which method yielded recordings of higher quality, and which factors influenced the quality of the cardiotocogram. It was found that the proportion of good-quality recordings was higher with ultrasound cardiography than with abdominal electrocardiography. The higher information content of the latter technique allows a more accurate assessment of the cardiotocograms. The recording quality is affected by numerous factors, the most important of which are adiposity and the duration of pregnancy. The use of abdominal electrocardiography is preferred in case of a thick abdominal wall, whereas the ultrasound technique is recommended between the 28th and 36th weeks of pregnancy.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The effects of the natural gonadotropin releasing hormone (LH-RH) and of a long-acting analogue, desgly10-D-leu6-LH-RH ethylamide, on the serum FSH, LH, testosterone and oestradiol-17 beta levels were studied in healthy men. The basal value for FSH was 3.58 +/- 0.47 mU/ml (SE), for LH 6.33 +/- 1.19 mU/ml. Following an intravenous dose of LH-RH the values increased by 3.40 +/- 0.88 and 25.99 +/- 5.67 mU/ml, respectively. After intravenous administration of the long-acting analogue, the peak FSH exceeded the basal value by 12.89 +/- 6.95 mU/ml, while LH increased by 41.27 +/- 4.72 mU/ml. The effect of the analogue on FSH and LH lasted 693 min and 862 min, respectively. Neither preparation changed the serum testosterone or oestradiol-17 beta levels essentially. The results suggest that the long-acting variant of LH-RH is more suitable than the natural hormone for examination of the FSH and LH reserves in men.
A non-stress test was applied to 186 women with high-risk pregnancy, and an oxytocin provocation test was added immediately. Increased frequency or acceleration of foetal heart rate accompanied by foetal movement was defined as "reactive" and interpreted as good condition of the foetus. Absence of accelerations adequate in number and magnitude within 30 minutes from testing was considered as alarming. Such tests were defined "non-reactive". Such situations could be attributed to temporary hypoxia or sleep of the foetus. Both the number of positive oxytocin provocation tests and perinatal morbidity were higher with significance (p less than 0.001) in the "non-reactive" group. One perinatal death occurred in that group. The non-stress test proved to be a non-invasive, harmless method and highly reliable for screening of women for high-risk pregnancy. It enabled better economy of cost and time and in the use of equipment.
Explore the source record for details and available documents.
Using radioimmunoassay method, we have estimated the levels of cortisol (C), pregnenolone (delta 5P), 17-hydroxypregnenolone (17-OH-delta 5P), dehydroepiandrosterone (DHEA), 17-hydroxyprogesterone (17-OH-P), androstenedione (A), testosterone (T) and dihydrotestosterone (DHT) in peripheral plasma samples collected at short-time (15 min) intervals from 10 fertile men, during two 4-h periods (06.00 to 10.00 and 18.00 to 22.00). In addition, the levels of biologically active luteinizing hormone (LH) were measured by an in vitro bioassay method in 9 of the subjects. The levels of all steroids studied exhibited diurnal variation with higher levels during the morning and lower levels during the evening period. The cortisol and the delta 5-steroid levels also exhibited individual short-term episodic spikes during the 2 periods. No short-term variation was observed in the levels of 17-OH-P, A, T and DHT. Statistically significant correlations were found between the levels of C and those of the delta 5-steroids and A in most of the subjects. No correlation was found between the above steroid levels and those of 17-OH-P, T and DHT. Also the LH levels exhibited episodic spikes of 60 to 90 min duration, but no diurnal variation. When the LH levels were related to those of T found in the same samples or in samples withdrawn 15 to 810 min afterwards, a significant positive correlation was found on repeated occasions in 5 of the 9 subjects. No systematic negative correlation was found when the T levels were related to those of LH in the same sequential fashion. Whereas the positive correlations found between LH and T levels in some of the subjects might suggest that physiological changes in peripheral LH levels are instrumental in regulating T-secretion, the rather consistent lack of significant negative correlation between T and LH levels seems to favour the view that the release of LH is not modulated by peripheral testosterone levels alone.
Explore the source record for details and available documents.
Explore the source record for details and available documents.