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Biomedical subjects

G Börsch

Publications and source records attributed to G Börsch.

At least 19 recordsLinked to original sources
PubMed1992

[Upper intestinal endoscopy in 188 bronchial cancer patients and 118 breast cancer patients with abdominal symptoms. The GI Metastases Study Group].

With the aim of analysing the pathological findings of upper gastrointestinal endoscopy in patients with bronchial or breast cancer and gastrointestinal symptoms a multicenter study was carried out over one year (1990) by 26 medical departments. One duodenal metastasis was verified among 188 patients with lung cancer. Seven of 118 patients with breast cancer developed symptomatic stenosis of the esophagus. A total of 42.9% of the patients with lung cancer and 38.6% of the patients with breast cancer had pathological findings detected by upper gastrointestinal endoscopy. Most frequent findings were duodenal and gastritic ulcers (lung cancer 15.0%, breast cancer 15.8%), esophagitis (lung cancer 16.3%, breast cancer 8.9%) and symptomatic stenosis of the esophagus (lung cancer 9.5%, breast cancer 7.0%). The authors conclude that there is a high frequency of relevant pathological upper gastrointestinal tract findings in symptomatic patients with breast or lung cancer, but that true metastatic disease is a rare phenomenon with the exception of metastatic involvement of the esophagus.

Aged↗
PubMed1992

[Bleeding gastric and duodenal varicose veins: endoscopic embolisation using tissue adhesives].

Endoscopically guided intravascular injections of the tissue glue N-butyl-2-cyanoacrylate have since 1990 been performed in eight patients (seven men, one woman; median age 59.5 [40-72] years) with cirrhosis of the liver (alcoholic: n = 6, posthepatic, n = 2), decreased haemoglobin (6-10 g/dl) and transient shock symptoms (n = 5) due to gastric (n = 7) or duodenal varices (n = 1). Gastric acid production was suppressed with omeprazole. Neither balloon catheters nor drugs were used to lower portal vein pressure. Initial haemostasis was achieved in all patients. One patient with consumption coagulopathy died of recurrent bleeding from varices in the body of the stomach which could be only temporarily arrested. Another patient had a recurrence of bleeding from varices in the cardia 3 months after the initial treatment: it was again controlled by endoscopic sclerotherapy with tissue glue. All other patients remain free of bleeding after a mean observation time of 8.4 months.

Adult↗
PubMed1992

[Short-term therapy with high dosage omeprazole and amoxicillin for Helicobacter pylori eradication. A pilot study].

In an open study, 50 patients with Helicobacter pylori-associated ulcer disease or severe functional dyspepsia were treated over one week with 2 x 40 mg omeprazole in the morning and evening preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. Fourty-seven patients (ulcer disease: n = 40, functional dyspepsia: n = 7) completed the study without contravening the protocol. The proportion of Helicobacter pylori eradication four weeks after cessation of study medication was 61.7% (29/47 patients) as judged from negative biopsy urease test, specific culture and histology after modified Giemsa staining. Three patients experienced side effects (stomatitis, self-limiting diarrhea, allergic exanthema).

Amoxicillin↗
PubMed1992

Two weeks treatment with amoxicillin/omeprazole for eradication of Helicobacter pylori.

In an open study, 62 patients with Helicobacter pylori-associated ulcer disease or functional dyspepsia were treated for two weeks with 2 x 20 mg omeprazole preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. 57 patients (active ulcer disease: n = 53, functional dyspepsia: n = 4) completed the study without contravening the protocol. The rate of eradication of the bacteria at least 4 weeks after cessation of study medication was 82.5% (47/57 patients). Three patients experienced side effects during the treatment period (stomatitis, self-limiting diarrhea, allergic exanthema). In one case allergic exanthema led to discontinuation of therapy. 11 patients with H. pylori-associated ulcer disease received 2 x 20 mg omeprazole for two weeks. In this group no eradication of bacteria was observed.

Amoxicillin↗
PubMed1991

[Diagnosis of Helicobacter pylori colonization of the gastric mucosa. A prospective comparative study of direct test methods and validation of a new urease test].

A prospective study including 119 patients submitted for routine endoscopy of the upper gastrointestinal tract was initiated to compare three commercial biopsy urease tests with regard to sensitivity and specificity in detecting Helicobacter pylori colonization of the gastric mucosa and their reaction velocity. Specific culture, microscopy after staining with methylene-blue, histologic search after modified Giemsa staining and the combined results of culture and histology ("true standard") served as reference methods. The sensitivity and specificity of all three tests were high: Angass urease test 92.0%/97.7%, Telen-Quick test 94.7%/100%, CLO-test 94.7%/100% (analysis of one antrum and one body biopsy in a single test kit). Telen-Quick and CLO-tests reacted faster than the Angass urease test, but a period of 24 hours was necessary for all three tests to detect "true negatives". Histology and microscopy were reliable reference methods concerning sensitivity and specificity, while culture was characterized by inferior sensitivity (78.6%) and high specificity (100%).

Adolescent↗
PubMed1991

[Endoscopic laser therapy. Indications, effectiveness and cost analysis in a medical department].

Between June 1985 and December 1988, 297 endoscopic laser procedures were performed in 130 patients. The indications comprised hemostasis, coagulation of potentially bleeding lesions, palliative tumor therapy in the upper and lower gastrointestinal tract and in the tracheobronchial tree, eradication of adenomas after incomplete snare resection, and recanalization of benign esophageal/cardiac strictures and postoperative colonic stenoses. In addition, an endoscopically introduced biliary endoprosthesis was shortened. Treatment was highly effective, and the complication rate less than 1%. The average operating cost of the laser equipment was DM 80 per application, increasing to 430 DM when account was taken of the high purchasing price of the laser.

Cost-Benefit Analysis↗
PubMed1991

Chronic active gastritis after eradication of Campylobacter (now: Helicobacter) pylori. Results of a medium term follow-up study.

11 patients with C.p.-associated chronic gastritis underwent a triple therapy with bismuth-subsalicylate, amoxicillin susp. and metronidazole. The C.p.-status and the inflammation parameters "polymorphonuclear leucocytes in the epithelium". "polymorphonuclear leucocytes in the lamina propria", "lympho-plasmacellular infiltrate in the lamina propria", "congestion and edema of the lamina propria" and "inflammatory alteration of the epithelium" were determined semi-quantitatively in semi-thin-sections by light microscopy in the same sections. The C.p.-status was verified further by means of the CLO-test and cultures. The biopsy probes were taken before treatment, immediately after treatment, 1 month following treatment and in differing time intervals up to 9 months following treatment. Eradication of C.p. could not be attained in 2 of the patients. Spherical forms and vibrioforms of C.p. exhibiting degenerative alterations could be demonstrated by electron microscopy. Throughout the study the inflammatory parameters "intraepithelial polymorphonuclear leucocytes", "polymorphonuclear leucocytes in the lamina propria", "inflammatory alterations of the epithelium" showed concordance in their reactions. They were closely correlated with the light microscopical demonstration of C.p.-organisms in the biopsy specimens. The regression of the lympho-plasmacellular infiltrate was still incomplete after 5 months of eradication. The time relationship between the end of treatment and complete remission differed. The results of our studies suggest that C.p. was the sole etiological factor for the development of chronic active gastritis in at least 4 of the 11 patients.

Chronic Disease↗
PubMed1991

[Ciprofloxacin-omeprazole combination therapy for eradication of Helicobacter pylori].

20 H. pylori-positive patients with gastric or duodenal ulcer disease (n = 16, one with proof of gastric cancer obtained by histology) or severe non-ulcer dyspepsia (n = 4) were entered in a pilot study to examine the effect of a combination of omeprazole (40 mg) before breakfast and ciprofloxacin (2 x 500 mg) 1 hour after meals for 1 week to treat Helicobacter pylori (Hp). The eradication rate was 15% (3 out of 20 patients) 4 weeks after therapy. Ulcer healing occurred in 2 of 3 patients having eradication and 9 of 11 control patients with positive H. pylori urease test and/or culture 4 weeks after treatment. Despite some good theoretical background, this drug combination is inefficient to eradicate H. pylori and cannot be recommended for routine clinical practice. No major side effects of the therapy-regimen were observed.

Administration, Oral↗
PubMed1990

[Bowel cleansing prior to colonoscopy. A prospective, randomized, blind comparative study].

A randomized, prospective, single blind study was performed in 90 hospital inpatients to compare the effect of three different bowel preparatory regimens prior to total colonoscopy. The extend of bowel cleansing, acceptance by the patients, side effects as well as body weight, blood pressure, pulse rate and various laboratory parameters served as major assessment criteria. Peroral colonic lavage was superior to a senna preparation and a combined laxative agent with regard to the extend of bowel cleansing (p less than 0.001). The study failed to detect significant differences in terms of acceptance by the patients between the three study groups. Minor deviations were found after the combination laxative (slight decrease of serum potassium levels by 0.32 mmol/l), after the senna preparation (minimal decrease of the heart rate), and after peroral lavage (slightly less weight reduction) as compared with the other study groups, respectively. We conclude that peroral lavage is significantly more effective with regard to the extend of bowel cleansing, when compared with two other bowel preparatory regimens, which use a senna preparation or a laxative combination, respectively. Likewise, this study failed to detect significant differences in terms of acceptance by the patients.

Adult↗