PubMed Health⌕ Search

Biomedical subjects

G Băcanu

Publications and source records attributed to G Băcanu.

17 recordsLinked to original sources
PubMed1991

[The early detection of diabetes mellitus and the active dispensary care of 1200 subjects with a genetic predisposition].

Diabetes mellitus (DM) is a metabolic disease with a long-lasting chronic course, attending during its development by complications which affect the state of health and require additional measures from the social and economic point of view. The current strategy consists in the earliest possible detection of disease in groups of population selected according to the existent risk of developing a DM. This action is followed by an active dispensary care and by lessons of health education, aimed at preventing metabolic decompensations and the early occurrence of degenerative chronic complications. Taking into account these considerations in the present paper, authors analyse the possibility of detection of DM in 1,200 subjects genetically predisposed, a special stress being laid on the means of prevention, on the role of active dispensary care and on the place of health education in the therapy of DM and in the prevention of complications of this disease with an invalidating potential.

Adult↗
PubMedDate not supplied

[Control of the metabolic state of diabetic patients by determining the concentration of serum glycosylated proteins (the fructosamine test)].

The method for determining glycosylate serum proteins is based on the ketoamines property (fructosamine) of reducing nitro-tetrazoline blue, in alkaline medium, to a coloured, photometric product. The technique is simple, rapid, reproducible and cheap. The method was used for investigation of 52 diabetics and 17 normal subjects. The normal values were between 1.50-2.70 mmol/l, uncertain between 2.70-3.00 mmol/l, and certainly pathological above 3.00 mmol/l. The level of serum fructosamines shows the glycemia variations for an average period of about two weeks, before determination. It is one of the valuable parameters for detecting and following the patients with diabetes mellitus, and has also a prognostic value in the evolution of the disease.

Adolescent↗
PubMedDate not supplied

Contribution to the early diagnosis of diabetes mellitus.

The authors present the results of an investigation for diabetes mellitus (DM), in a selected group of 9,901 persons at high risk for the disease, using oral glucose tolerance test (OGTT). In the group investigated they included 4,753 diabetic blood relatives, 4,123 obese patients and 935 women who delivered big babies. The percentage of diagnosed DM was 30.58 for the entire group, with variations between: 39.47 in the obese, 27.27 in women with macrosomia, and 23.35% in the diabetic blood relatives. The results showed the value of OGTT as a diagnostic tool, the importance of early diagnosis and the necessity of careful long time follow-up of the newly diagnosed diabetics.

Adolescent↗
PubMedDate not supplied

Determinants of microalbuminuria in diabetics.

Several risk factors for the development of microalbuminuria such as: blood glucose unbalance, high blood pressure, dyslipidemia, genetic susceptibility have been described and discussed. The object of this study was to ascertain the importance of these factors. To this end albuminuria was measured using MICRAL-test in two groups of subjects: 100 diabetics (43 type I (insulin-dependent) and 57 type II (non insulin-dependent), and 54 controls. According to diabetes duration, the cases were divided into four sub-groups (less than 5 years; 5-9 yrs; 10-19 yrs; over 20 yrs). The mean values of albuminuria were assessed in the two groups (diabetics and controls) and also for each subgroup of diabetes duration. It was found that in insulin-dependent diabetes mellitus (IDDM), the duration of the disease is an important determinant of albuminuria, a significant increase in its values being observed after 10 yrs of diabetes evolution. The importance of diabetes duration, glucose unbalance and high blood pressure (BP) as possible determinants of microalbuminuria was assessed by comparing the micro- and normoalbuminuric diabetics. Our results are similar to those reported by many other authors, showing that these are important risk factors for microalbuminuria, especially in IDDM.

Adult↗
PubMedDate not supplied

Apolipoproteins AI and B and plasma lipid values in well-treated diabetic patients from Romania.

This review is aiming to study the values of apolipoprotein AI and B and plasma lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride) in well-treated diabetic patients, and their possible relationship with hemoglobin A1, body mass index and insulin levels. The study groups were 26 insulin-dependent diabetic (IDDM) patients, 30 non-insulin-dependent diabetic (NIDDM) subjects and 20 non diabetic subjects (controls). Apolipoprotein AI concentrations were similar in the three groups, but apolipoprotein B values and apo B/apo AI ratio were significantly higher in IDDM as related to NIDDM patients (p < 0.001) and to non-diabetic subjects (p < 0.001). We were not able to find significant differences concerning plasma lipid values between the three groups. We found a weak correlation between apo B and hemoglobin AI in IDDM (r = 0.45; 0.02 < p < 0.05), but not in NIDDM patients. Body mass index was not related to the values of apolipoproteins AI and B. We found a positive but weak correlation between insulin levels and triglyceride (r = 0.42), and an inverse one with HDL cholesterol (r = 0.57; 0.02 < p < 0.05) in non-diabetic subjects only, while in NIDDM patients these associations were even less significant. Plasma insulin values strongly correlate to body mass index in both NIDDM (r = 0.64; p < 0.001) and in control subjects (r = 0.73; 0.001 < p < 0.001).

Adult↗