Biomedical subjects

G Baigal

Publications and source records attributed to G Baigal.

3 recordsLinked to original sources

PubMed2006

Assessment of 2 cervical screening methods in Mongolia: cervical cytology and visual inspection with acetic acid.

OBJECTIVE: The aim of the study was to evaluate the test parameters of visual inspection with acetic acid (VIA) and cervical cytology in 3 Mongolian aimags. METHODS: From February 18, 2002, to December 12, 2004, sexually active women, 30 years or older who had never been screened, underwent cervical cytology and VIA in the aimags' central hospital. Women with abnormal test results and 5% of women with normal results were recommended to have colposcopy with or without biopsy. RESULTS: Two thousand nine women underwent both tests. Visual inspection with acetic acid was abnormal in 254 (12.6%); Pap smear showed atypical squamous cells of undetermined significance or worse in 3%. Using cervical intraepithelial neoplasia 2 or higher disease on biopsy as the end point, the test parameters for VIA are sensitivity of 82.9% (95% CI = 81.3%-84.5%), specificity of 88.6% (95% CI = 87.2%-90.0%), positive predictive value of 12.2% (95% CI = 10.8%-13.6%), and negative predicative value of 99.7% (95% CI = 99.5%-99.9%). The test parameters for Pap smear are sensitivity of 88.6% (95% CI = 87.2%-90.0%), specificity of 98.5% (95% CI = 98.0%-99.0%), positive predictive value of 51.7% (95% CI = 49.5%-53.9%), and negative predicative value of 99.8% (95% CI = 99.6%-100%). CONCLUSION: Visual inspection with acetic acid has an acceptable test parameter for population-based cervical screening in Mongolia.

Acetic Acid↗

PubMed2002

Risk factors for ovarian cancer and early-onset breast cancer in Mongolia.

OBJECTIVE: To determine if there are founder BRCA1 mutations in the Mongolian population. METHODS: Seventeen women with ovarian cancer, 14 women with premenopausal breast cancer and one woman with both cancer types were interviewed to obtain family history, and hormonal, reproductive and environment risk factor information. Blood was collected for DNA analysis from these women to determine the frequency of BRCA1 and BRCA2 mutations in Mongolia. RESULTS: Two patients had two first-degree relatives with cancer and nine women had one first degree relative with cancer. Two women had the unique BRCA1 mutation previously described. These two women were not related but their parents were from the same tribe and they lived in the same imak (province). Only one other patient was of this tribal background and from the same region; however, she did not have the BRCA1 mutation. CONCLUSION: A substantial proportion of Mongolian woman with ovarian cancer or early-onset breast cancer may be due to a founder BRCA1 mutation 3452delA.

Adult↗

PubMedDate not supplied

A unique BRCA1 mutation identified in Mongolia.

This is a case report of genetic assessment conducted on a family residing in the third world where two sisters have presented with early onset ovarian cancer. Protein truncation testing and DNA sequencing identified a unique mutation on exon 11 (3452delA) of the BRCA1 gene. Buccal swab testing of three siblings and three offspring showed that half of the family members carried the same mutation. Currently, genetic testing in third-world countries is conducted within research budgets, as testing is not affordable or locally available for such high-risk families. Unique mutations in the BRCA1 gene that are expressed in geographically isolated groups will be useful in genetic counseling and preventative maneuvers. The only preventive management strategy available in the third world is prophylactic surgery.

Adenocarcinoma↗