PubMed Health⌕ Search

Biomedical subjects

G Balázs

Publications and source records attributed to G Balázs.

9 recordsLinked to original sources
PubMed1992

Rapid cytological diagnosis during thyroid surgery.

The authors report the results of the use of intra-operative cytological examinations of the thyroid gland. In their hands, the method has a 96.3% accuracy in 757 patients with thyroid disorder. Benign conditions and malignant tumours can be correctly diagnosed. False negative diagnosis can arise with well-differentiated follicular carcinoma and the differentiation of follicular adenoma may be difficult. Atypical adenomas may give a false positive diagnosis. The incorrect diagnosis of chronic lymphocytic thyroiditis is unlikely when sufficient attention is given to the whole clinical picture.

Cytodiagnosis↗
PubMed1979

Cytofluorimetric measurements on the DNA contents of tumor cells in human thyroid gland.

The relative DNA contents of thyroid cell nuclei were measured in surgically removed thyroid tissue of 50 patients by means of cytofluorimetry. Smears were prepared immediately after removal of the thyroid nodules according to the classical Feulgen technique. The fluorescence intensities were always compared with those of healthy thyroid tissue prepared in the same way. In each case samples were investigated by the usual histology. The observations indicate that differentiated carcinomas of thyroid gland have an increased DNA content of nuclei, at about the tetraploid level. Among them the follicular carcinomas (11 cases) showed an even higher DNA content of about 250% of the diploid level. Frequency distribution of the cell pools studied revealed a widely scattered aneuploidization of the malignant tumor cells. The benign adenomas displayed only a moderate increase of nuclear DNA content reaching only about 130% of the diploid value. Among the 22 adenomas classified histologically as of benign character, two cases showed very highly increased and widely scattered DNA contents. These latter two cases might be in process of malignant transformation. DNA cytofluorimetry may contribute to a more safe differential diagnosis of the "follicular neoplasia" of the thyroid gland.

Adenocarcinoma↗
PubMed1979

T and B lymphocytes in lymph nodes and spleen of patients with Hodgkin's disease.

Lymphocyte surface markers of 100 tissue specimens (67 lymph nodes and 33 spleens) of 40 patients with Hodgkin's disease were studied by means of spontaneous E-rosette formation and direct immunofluorescence method. The occurrence of active and total T cells was signigicantly higher (p less than 0.001) in the tumor-involved lymph nodes and spleens, while the frequency of B cells was practically the same in the histologically negative lymph nodes and spleens. In the tumorous spleen of 6 untreated patients the frequency of active and total T cells was higher in the tumorous tissue specimens than in the surrounding histologically negative tissue specimens. No correlation has been found between the simultaneously investigated peripheral T and B cell counts, clinical stage and the histological type of the tumor.

B-Lymphocytes↗
PubMed1979

[Clinical and morphological properties of cold nodules formed in the thyroid gland of patients treated with I-131 for hyperthyreosis].

The authors report on the clinical and morphological features of patients who had been previously treated for toxic adenoma with different doses of 131I isotope, and were then operated on for cold nodule. Progressive pseudoatypic and Hürthle-cell transformations, which are difficult to distinguish from different-type thyroid carcinomas, were revealed in one and a solid anaplastic carcinoma in another of the five patients during histological examination of operative specimens in serial sections. On the basis of these findings the authors support the function-protective operative treatment of single toxic adenomas, although the causal relationship between isotope treatment and consecutive carcinoma can not be verified unanimously.

Adenoma↗
PubMed1978

[Simultaneous occurrence of hyperthyreosis and thyroid carcinoma].

The authors report on the morphological and clinical features of occult thyroid carcinomas confirmed by detailed histological examinations following the surgical treatment of hyperthyreotic goiters recurrent after prolonged thyreostatic treatment, as well as on the follow-up data of the patients. Joint occurrence of hyperthyroidism and thyroid tumors was observed in five patients, two of whom showed progressive endocrine ophthalmopathy. In the surgical preparations of three patients, chronic lymphocytic thyroiditis was also diagnosed. On the grounds of postoperative care, the authors draw conclusions of practical clinical significance. They take a stand on the questions of surgical and adjuvant treatment favored by them in the case of the joint occurrence of the two diseases.

Adenocarcinoma↗
PubMed1977

[The unrecognized thyroid neoplasm].

During the last 10 years the authors operated upon 8 patients with illnesses beginning with different lung alterations. In all cases the basic illness was a papillary or papillo-follicular cancer of the thyroid gland which later was found indirectly after other operation and histologic examination. By evaluation of clinical symptoms, operative and morphologic findings conclusions as well as the results of reexamination the authors draw conclusions as to the biological attributes of this tumor type. They recognize that the carcinomas of the thyroid gland cause metastases of regional lymph nodes or distant lung metastases approaching the TO stage. Lung metastases appeared in different shapes and were in all cases the fist clinical sign of the basic illness. Considering the biological attributes of this tumor the authors emphasize that it is not inoperable or untreatable.

Adenocarcinoma↗