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Biomedical subjects

G Baldursson

Publications and source records attributed to G Baldursson.

6 recordsLinked to original sources

[Medication use and treatment characteristics of children referred to the outpatient ADHD-clinic at the Department of Child and Adolescent Psychiatry, the National University Hospital.].

MATERIAL AND METHODS: Data was accumulated by retrospectively looking at the records of 102 children of both sexes between 3 and 15 years of age, referred to the ADHD outpatient clinic during the period June 1, 1998 - May 31, 1999. A semi-structured diagnostic parent interview was used to assess childhood psychiatric disorders according to ICD-10. The ADHD Rating Scale- IV, the Home Situations Questionnaire and the Child Behavior Checklist were completed by the parents. Teachers filled out the ADHD Rating Scale and the Teacher Report Form as well as a form evaluating the child's academic progress. To assess intellectual functioning, WISC-III or WPPSI-R were administered. Medical evaluation was performed and drug treatment recorded. RESULTS: Seventy-two children fulfilled ICD-10 diagnostic criteria of hyperkinetic disorder. High rates of other behavioural disorders, especially oppositional defiant disorder and a significant frequency of emotional disorders were recorded. Nearly two-thirds of the children had been started on medication prior to referral, most often amytryptiline and methylphenidate. Eleven children received combined pharmacotherapy but 35% had not received any drug treatment. Psychopharmacotherapy for most of the children was started between the age of four and eight years. Behaviour management counselling and parent training was recommended in most cases. CONCLUSIONS: Thirty children did not meet full hyperkinetic disorder diagnostic criteria, but these children may nonetheless have manifested high levels of symptoms. Most of the children were started on tricyclic antidepressants rather than stimulants which is unusual compared with international research and practice. The reason is unclear but may reflect the high rate of comorbidity but also doctors' preferences.

English Abstract↗

[Hyperkinetic disorder. A review.].

Attention-deficit/hyperactivity disorder or hyperkinetic disorder is a clinically defined syndrome characterised by age inappropriate deficits in sustained attention, impulsivity and overactivity. Despite extensive investigation, a specific neuroanatomical, physiological, biochemical, or psychological origin has not been identified. Diagnosis is based on detailed medical and developmental history, symptom rating scales, psychological assessment and medical evaluation. Increases in diagnosis and treatment of the disorder have elicited public and professional concern. The main focus in this article is on this disorder in children and adolescents and includes practical information on assessment and treatment. Other disorders, which may be either comorbid with or mistaken for hyperkinetic disorder, are reviewed in less detail.

English Abstract↗

Tumours in Iceland. 14. Malignant tumours of soft tissues. Histological classification and epidemiological considerations.

All malignant tumours of soft tissues diagnosed in Iceland between 1955 and 1988 were reviewed histologically. Of a total of 155 tumours, 129 were, on review, soft tissue sarcomas, while 26 had been erroneously diagnosed and were excluded from the study. In 25% of the tumours the original sarcoma diagnosis was changed to another sarcoma type. Malignant fibrous histiocytoma, liposarcoma and leiomyosarcoma together comprise more than half of all tumours diagnosed. Contrary to previous estimations, according to this study, the age-standardized incidence of soft tissue sarcoma in Iceland is 1.8 per 1000,000 for males and 1.6 per 100,000 per females, which is similar to incidence rates in the other Nordic countries. The majority of sarcomas were of relatively high grade. The tumours were graded using both three and four grades of malignancy. Both systems yielded prognostic information although it was not possible to detect significant differences in survival for grade I and grade II tumours when the four grade system was used. The results of this study show that the epidemiology of soft tissue sarcoma in Iceland is similar to that found in other Western countries.

Age Factors↗

Soft tissue sarcomas in Iceland 1955-1988. Analysis of survival and prognostic factors.

From 1955 to 1988 a total of 129 cases (69 males and 60 females) of soft tissue sarcomas were diagnosed in Iceland, four at autopsy. The median age was 55 years (0-91). All the cases have been reviewed clinically and histopathologically and graded on both a three- and a four-point scale. The average age-standardized incidence was 1.8/100,000 for males and 1.6 for females. The tumour was most often localized in the thigh and retroperitoneal space. The most common histologic subtypes were malignant fibrous histiocytoma (22.5%), liposarcoma (18.6%) and leiomyosarcoma (16.3%). The 5- and 10-year survival rates (n = 125) were 38% and 29% respectively. Cox's multivariate analysis was performed on the following prognostic factors: age, sex, tumour localization, histopathologic subtype, tumour size, malignancy grade and year of diagnosis. The strongest prognostic factor was malignancy grade (IV vs I; p less than 0.001 and RR = 5.35 and III vs I; p = 0.017 and RR = 2.01) followed by tumour size (pT2 vs pT1; p less than 0.001 and RR = 3.09 and pT3 vs pT1; p = 0.002 and RR = 3.40) and year of diagnosis (p = 0.003 and RR = 0.96; corresponding to a 54% reduction in mortality risk during a 20-year period).

Age Factors↗

Prognostic significance of lymph node status in stage III breast cancer.

Case histories of 103 patients with locally advanced (stage III) breast cancer have been reviewed. Ninety of the patients were judged operable. The median follow-up time was 52 months. The 5-year survival rate for the whole group was 54%. The 5-year relapse-free survival rates for the pN0, pN1 and pN2-3 were 91, 50 and 19% respectively and the 5-year survival rates for the groups were 86, 53 and 30% respectively. These results underline the heterogeneity and the very different prognoses for the different subgroups in stage III breast cancer patients. A reevaluation of the staging system is therefore suggested.

Adult↗

Temporomandibular joint symptoms in patients with midfrequency sensorineural hearing loss.

It was hypothesized that a correlation exists between a specific form of sensorineural hearing loss and temporomandibular joint dysfunction and/or parafunction, with the audiometric configuration of the loss showing a notch (poorest threshold) at 1000 or 2000 Hz in the range from 250 through 4000 Hz. Fifty patients at audiology clinics who showed this audiometric configuration were compared with 50 control patients, matched for age, sex, and severity of loss. The midfrequency notch group reported more symptoms of temporomandibular joint dysfunction (p less than 0.005), including more temporomandibular joint pain (p less than 0.0001), tenderness (p less than 0.025), and jaw noises (p less than 0.05). The notch group also reported significantly more bruxism (p less than 0.001) and clenching (p less than 0.001). Patients found having this midfrequency notch have been predominantly female (64% in this study), the percentage who are female increasing with age. The findings demonstrate a relationship between the form of sensorineural hearing loss studied and symptoms of temporomandibular joint dysfunction.

Adolescent↗