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Biomedical subjects

G Banerjee

Publications and source records attributed to G Banerjee.

33 records · Page 2Linked to original sources

Mannose-coated liposomal hamycin in the treatment of experimental leishmaniasis in hamsters.

Liposomal hamycin was found to elicit enhanced microbicidal activity and reduced toxicity in experimental leishmaniasis in a hamster model under in vivo conditions. Mannose-coated liposomal hamycin was seen to produce increased therapeutic efficacy as judged from the lowering of spleen parasite load. At an equivalent dose of 0.5 mg/kg, every 3 days for a total of three doses in 7 days, the mannose-coated liposomal hamycin was found to be most effective compared to either of the liposomal hamycin or the free hamycin. Because of the reduced toxicity as judged from the blood pathology, tissue histology, and specific enzyme level related to normal liver function, mannose-coated liposomal hamycin resulted in 80 to 100% survival for a period of 15-18 days. Hamycin intercalated in sterol-rich liposomes showed reduced hemolytic activity but comparable therapeutic efficacy as was found with ordinary liposomes.

Animals↗

Is hysteria on the wane? A community survey in West Bengal, India.

A field survey was conducted in two villages--Gambhirgachi and Paharpur--in 1972. The survey was repeated after 10 years in the former village and after 15 years in the latter one. The second survey showed very little change in the rate of total mental morbidity. The rate of prevalence of hysteria declined significantly in both villages. In Gambhirgachi the rate of hysteria dropped from 16.9 to 4.6 per 1000 in 10 years, and in Paharpur it dropped from 32.3 to 2.05 per 1000 in 15 years.

Adolescent↗

Imerslund-Grasbeck syndrome in a Libyan boy.

Immerslund-Grasbeck syndrome is an uncommon disease, characterized by megaloblastic anaemia and persistent proteinuria. A Libyan boy with the characteristic findings is presented. He received intramuscular vitamin B12 injections and there followed a remarkable clinical and haematological improvement.

Anemia, Macrocytic↗

Foreign bodies in the tracheobronchial tree: a review of 102 cases in Benghazi, Libya.

A total of 102 children in whom foreign body aspiration was suspected were admitted to hospital and their records reviewed. Bronchoscopy was performed on all except two who coughed out the foreign body. In 76 cases (group A), foreign bodies were identified in the tracheobronchial tree. In the remaining 26 (group B), no foreign body was found. Boys predominated over girls. Most of the foreign bodies were lodged on the right side. The commonest foreign body was the peanut. Clinical and radiological features in group A were not diagnostic; in many instances, therefore, the threshold of suspicion of aspiration should be low. Hence, medical personnel and the public should be made more aware of this problem.

Bronchi↗

Ehlers Danlos syndrome--masquerading as primary muscle disease.

A 9 year old Libyan boy presented with a history of delayed walking and abnormal gait. The presence of marked muscle under-development with hypotonia led to the initial diagnosis of primary muscle disease; later, he was found to have hyperelastic, fragile skin and hypermobile joints-the cardinal features of Ehlers Danlos syndrome. In this instance the disease seems to have been inherited in an autosomal recessive manner.

Child↗

Heroin dependence.

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Heroin Dependence↗

Epidemic koro in West Bengal, India.

The present study draws attention to the recent sudden outbreak of Koro in epidemic form in the rural areas of West Bengal, India. The details of three such cases are reported.

Adolescent↗

Socio-economic status and mental morbidity in certain tribes and castes in India--a cross-cultural study.

The authors made a field-survey of mental morbidity in all the tribal and caste groups residing in a cluster of villages in West Bengal, India, and found that, in each group, higher socio-economic classes had higher rates of mental morbidity. Different groups having a similar cultural pattern showed no significant difference in their rates of morbidity. Groups having different cultural patterns differed significantly in their rates of morbidity. In the tribal groups some neurotic disorders were absent.

Cross-Cultural Comparison↗

Socio-economic status and prevalence of mental disorders in certain rural communities in India.

A psychiatric field-survey was conducted in three villages in West Bengal, India in order to correlate the prevalence of mental morbidity with the socio-economic status of the families. The sample was divided into four groups on the basis of religion or caste. Total morbidity had no statistically significant relationship with socio-economic status in any of the four groups. In the total sample it was directly related. Higher classes had significantly higher rates. Psychoses were not correlated with socio-economic status in any of the groups. Neuroses showed a significantly higher rate in the upper strata of two groups; in the other two groups the trend of prevalence was in the same direction. The four groups had significant differences in their rates of total morbidity. In all the groups females had a higher rate of mental morbidity. Psychoses, Neuroses and Depression were commoner in females and Schizophrenia was commoner in males.

Adolescent↗

A clinical evaluation of depressives found in a rural survey in India.

Those who were labelled as depressives in a rural survey were randomly divided into a Medicine group (who received antidepressive drug treatment), a Placebo group (who received placebo) and a Natural Process group (who received no treatment). The depth of their depression was assessed by Hamilton's Depressive Rating Scale before the beginning of the trial, on the 14th day and on the 28th day of trial. They were compared with a matched group of healthy controls and again with a matched group of depressives who attended an urban clinic for treatment. The results indicate that the rural depressives who never sought treatment voluntarily were not different from those who sought treatment in clinics, so far as their response to treatment is concerned.

Depression↗