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G Baquero

Publications and source records attributed to G Baquero.

3 recordsLinked to original sources
PubMed1977

Treatment of typhoid fever with fosfomycin alone and associated to chloramphenicol or ampicillin.

Treatment with fosfomycin alone and associated to subtherapeutic doses of chloramphenicol or of ampicillin, has been tried on 50 patients with typhoid fever and on four carriers of S. typhi in the Hospital del Rey. 15 patients were treated with fosfomycin alone, 22 with fosfomycin plus chloramphenicol and 13 with fosfomycin plus ampicillin. The treatment lasted 15-20 days. The results have been evaluated clinically and bacteriologically, haemo- and coprocultures being carried out. The sensitivity of the isolated germs has been studied, including MIC and the synergism in vitro between fosfomycin-chloramphenicol and fosfomycin-ampicillin. Fosfomycin, chloramphenicol and ampicillin determinations have been carried out on the blood. The cures obtained were 67, 82 and 92% respectively with fosfomycin, fosfomycin-chloramphenicol and fosfomycin-ampicillin. We believe that this antibiotic can be useful in the treatment of typhoid fever, associating it to chloramphenicol or ampicillin, due to the synergism existing between them and given the results we have obtained.

Administration, Oral↗
PubMedDate not supplied

[Gastrin levels in normal dogs subjected to truncal and selective parietal cell vagotomy].

Based upon the fact that there is an increase of serum gastrin levels after vagotomy, the authors compare normal gastrin levels in non-operated dogs, with two series of dogs submitted to truncal and parietal cells vagotomy (PCV), respectively. The surgical technique, as well as the method of gastrin determination employed are described herein. Three series of 7 dogs each were compared. A: "Normal"(non-operated) dogs; B: Dogs with truncal vagotomy and C: Dogs with PCV. The results of Mean values and P for every series were as follows: Series A: Mean 26 +/- 15.0 pg/ml. Series B: Mean 110 +/- 51.6 pg/ml. Series C: Mean 17.4 +/- 12.9 pg/ml. The relation of P showed high significance (P = 0,0004) between A and B; ("normal" vs truncal); slight significance(P = 0,128) between A and C ("normal" vs PCV) and again high (P = 0,0002) between B and C (truncal vs PCV). It is concluded that the rise in serum gastrin levels in dogs submitted to truncal vagotomy are highly significant when are compared with those in "normal" dogs. Dogs submitted to PCV showed slight rises in serum gastrin levels, without statistic significance when are compared with "normal" dogs, strongly indicating the near-physiologic effects of the PCV on the serum gastrin levels.

Animals↗