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Biomedical subjects

G Barbato

Publications and source records attributed to G Barbato.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Plasma levels of anti-arrhythmic drugs and clinical effectiveness in the treatment of ventricular arrhythmias].

In spite of the ratio between plasmatic concentration and antiarrhythmic effects of a drug many factors can be influenced by many factors, the plasma level monitoring plays an important clinical role. The efficacy of the antiarrhythmic therapy should be evaluated not only by means of ECG-Holter monitoring and/or electrophysiological study but also by the means of determination of plasmatic and tissular concentration of a drug and metabolites. This latter is indispensable in the evaluation of new antiarrhythmic drugs and of a dose/effect relationship during acute and chronic therapy.

Anti-Arrhythmia Agents↗
PubMed1983

[Idiopathic mitral valve prolapse].

Current knowledge concerning idiopathic prolapse of the mitral valve is illustrated. The histopathological cause is myxoid degeneration of the mitral cusps, which sometimes extends to the tendinous cords, the valve implant ring, and the apex of the papillary muscles. Primary damage to these structures, whose intactness is essential for correct closure of the ostium, causes protrusion of the ventricular cusps into the left atrium during ventricular systole (i.e. prolapse). The reason for this degeneration is not known. The high familial incidence of prolapse lends credit to the most widely held suggestion, namely a hereditary defect. The clinical progress is benign in the great majority of cases ("crystallized" form) and is often asymptomatic. Complications are possible, however, and must always be borne in mind. They include progressive and acute mitral insufficiency, infective endocarditis, arrhythmias, motor or sensitive neurological complications, and sudden death. Particular attention must be paid to the path to be followed to arrive at the correct diagnosis. Careful evaluation of some of the clinical signs arousing suspicion in the previous history and/or objective examination enable a diagnosis to be formed with relatively simple, non-invasive instrumental techniques, such as echocardiography and polycardiography, provided other forms of prolapse secondary to ischaemic heart disease, mitral endocarditis, etc. are excluded. "Therapy is obviously necessary in the presence of complications; however, even in "crystallized" form, in the presence of subjective symptoms, tranquillizers and possibly beta-blockers may be necessary".

Adrenergic beta-Antagonists↗